PT  - JOURNAL ARTICLE
AU  - Thomas C. Butler
AU  - William J. Waddell
TI  - THE ROLE OF THE LIVER IN THE DEMETHYLATION OF N-METHYL DERIVATIVES OF HYDANTOIN AND OF 2,4-OXAZOLIDINEDIONE
DP  - 1954 Feb 01
TA  - Journal of Pharmacology and Experimental Therapeutics
PG  - 241--243
VI  - 110
IP  - 2
4099  - http://jpet.aspetjournals.org/content/110/2/241.short
4100  - http://jpet.aspetjournals.org/content/110/2/241.full
SO  - J Pharmacol Exp Ther1954 Feb 01; 110
AB  - Partial hepatectomy in the rat results in a large decrease in the rate of demethylation of l-Mesantoin and of trimethadione. It is concluded that the liver is the principal, if not the only, site of the demethylation of these drugs. The suggestion is made that the liver is probably the principal site of demethylation not only of N-methyl derivatives of barbituric acid, hydantoin, and 2,4-oxazolidinedione but also of analogous compounds of other chemical types.