RT Journal Article
SR Electronic
T1 EFFECTS OF FREQUENCY OF STIMULATION ON THE PARALYZING DOSE OF NEUROMUSCULAR BLOCKING AGENTS
JF Journal of Pharmacology and Experimental Therapeutics
JO J Pharmacol Exp Ther
FD American Society for Pharmacology and Experimental Therapeutics
SP 165
OP 171
VO 107
IS 2
A1 James B. Preston
A1 E. F. Van Maanen
YR 1953
UL http://jpet.aspetjournals.org/content/107/2/165.abstract
AB The effect of frequency of stimulation on the paralyzing dose of Flaxedil, d-tubocurarine, decamethonium, neostigmine, and Tensilon was studied in the sciatic-gastrocnemius preparation of anesthetized rats. 1. For the frequencies tested (0.067 to 5.0 stimuli per second) increase in frequency of stimulation results in a decrease of the PD50 for all five agents. 2. The slopes of the dose-response curves do not differ significantly at the different frequencies of stimulation or among the five compounds. 3. Increasing the frequency of stimulation shortens the interval from injection to the time of peak effect. 4. The average rates of recovery of twitch height in per cent per minute are: Flaxedil 8.5, d-tuhocurarine 11.6, decamethonium 3.8, neostigmine 57.8, and Tensilon 53.2. They are not affected by frequency of stimulation in the range tested.