PT  - JOURNAL ARTICLE
AU  - Preston, James B.
AU  - Van Maanen, E. F.
TI  - EFFECTS OF FREQUENCY OF STIMULATION ON THE PARALYZING DOSE OF NEUROMUSCULAR BLOCKING AGENTS
DP  - 1953 Feb 01
TA  - Journal of Pharmacology and Experimental Therapeutics
PG  - 165--171
VI  - 107
IP  - 2
4099  - http://jpet.aspetjournals.org/content/107/2/165.short
4100  - http://jpet.aspetjournals.org/content/107/2/165.full
SO  - J Pharmacol Exp Ther1953 Feb 01; 107
AB  - The effect of frequency of stimulation on the paralyzing dose of Flaxedil, d-tubocurarine, decamethonium, neostigmine, and Tensilon was studied in the sciatic-gastrocnemius preparation of anesthetized rats. 1. For the frequencies tested (0.067 to 5.0 stimuli per second) increase in frequency of stimulation results in a decrease of the PD50 for all five agents. 2. The slopes of the dose-response curves do not differ significantly at the different frequencies of stimulation or among the five compounds. 3. Increasing the frequency of stimulation shortens the interval from injection to the time of peak effect. 4. The average rates of recovery of twitch height in per cent per minute are: Flaxedil 8.5, d-tuhocurarine 11.6, decamethonium 3.8, neostigmine 57.8, and Tensilon 53.2. They are not affected by frequency of stimulation in the range tested.