RT Journal Article SR Electronic T1 THE EFFECT ON BLOOD PRESSURE AND TOXICITY OF 1-(3-FLUOROPHENYL)-2-AMINOETHANOL AND RELATED COMPOUNDS JF Journal of Pharmacology and Experimental Therapeutics JO J Pharmacol Exp Ther FD American Society for Pharmacology and Experimental Therapeutics SP 440 OP 443 VO 106 IS 4 A1 A. M. Lands YR 1952 UL http://jpet.aspetjournals.org/content/106/4/440.abstract AB The results of this investigation have shown 1-(3-fluorophenyl)-2-isopropyl-aminoethanol and the N-methyl analog to be weak pressor agents. The primary amine is most pressor and this activity is diminished by alkyl substitution of the amine. When the amino alkyl group is larger than methyl, pressor action is lost and depressor effects are obtained. Depressor action is greatest with the N-isopropyl analog. The toxicity of 1-(3-fluorophenyl)-2-aminoethanol and the N-alkyl analogs is comparatively low. The most toxic compounds are the depressor amines wherein the N-alkyl group is propyl or butyl.