RT Journal Article
SR Electronic
T1 THE PHYSIOLOGICAL DISPOSITION AND BIOTRANSFORMATION OF DIBENAMINE AND A METHOD FOR ITS ESTIMATION IN BIOLOGICAL TISSUES
JF Journal of Pharmacology and Experimental Therapeutics
JO J Pharmacol Exp Ther
FD American Society for Pharmacology and Experimental Therapeutics
SP 166
OP 179
VO 106
IS 2
A1 Julius Axelrod
A1 Lewis Aronow
A1 Bernard B. Brodie
YR 1952
UL http://jpet.aspetjournals.org/content/106/2/166.abstract
AB Methods are described for the estimation of Dibenamine and one of its metabolites, dibenzylamine, in biological fluids and tissue. Factors concerned with the physiological disposition and metabolic fate of Dibenamine in the dog after intravenous injection have been studied. Part of the drug is rapidly metabolized and part is localized in fat where it is stable and from which it slowly diffuses into the bloodstream. There is close correlation between the adrenergic blocking activity and the concentration of drug in fat. No evidence that Dibenamine is hydrolyzed in the body to yield the corresponding alcohol was found. Most if not all the Dibenamine is dealkylated to form dibenzylamine. This compound is conjugated in part, probably by acetylation. The observations suggest that the hypotheds that Dibenamine acts irreversibly on a cell receptor through the active ethylenimmonium ion may require modification.