RT Journal Article
SR Electronic
T1 CHRONIC ORAL TOXICITY TESTS OF METHOXYCHLOR (2,2-DI-(P-METHOXYPHENYL)-1,1,1-TRICHLORETHANE) IN RATS AND DOGS
JF Journal of Pharmacology and Experimental Therapeutics
JO J Pharmacol Exp Ther
FD American Society for Pharmacology and Experimental Therapeutics
SP 60
OP 66
VO 104
IS 1
A1 Harold C. Hodge
A1 Elliott A. Maynard
A1 H. J. Blanchet, Jr.
YR 1952
UL http://jpet.aspetjournals.org/content/104/1/60.abstract
AB 1 . Groups of male and female rats, 25 each, were maintained on diets containing 0 (control groups), 0.0025, 0.020, 0.16 per cent methoxychlor for a period of two years. No effect on growth was noted in the rats given the 0.0025 and 0.020 per cent diets, respectively. A moderate growth reduction was evident in the rats given the 0.16 per cent diet. No decrease in life span was observed. Normal values were found in urine analyses, in a thorough series of periodic hematologic examinations, and in organ weights at autopsy. No histological changes were found that were attributed to the administration of methoxychlor. Little tendency for accumulation of methoxychlor in the tissues was found. 2. Two dogs were fed each of the following doses of methoxychlor for one year: 0 (control dogs), 20, 100, and 300 mgm./kgm./day. Two dogs died from intercurrent disease; in neither case was the cause of death related to the treatment. Hematological observations, urine analysis and organ weights lay within normal limits. No evidence of tissue damage was found histologically.