RT Journal Article
SR Electronic
T1 THE TOPICAL ANESTHETIC ACTIVITY OF AN ISOQUINOLINE COMPOUND
JF Journal of Pharmacology and Experimental Therapeutics
JO J Pharmacol Exp Ther
FD American Society for Pharmacology and Experimental Therapeutics
SP 306
OP 309
VO 103
IS 3
A1 Edwin J. Fellows
A1 Edward Macko
YR 1951
UL http://jpet.aspetjournals.org/content/103/3/306.abstract
AB 1. When applied to rabbit eyes, 1-(β-dimethylaminoethoxy)-3-butylisoquinoline monohydrochloride (Quotane) was found to he 1000 times more active than cocaine and ten times more potent than dibucaine. 2. Intraperitoneally in rats Quotane was 50 per cent less toxic than dibucaine and twice as toxic as cocaine. 3. Intravenously in rabbits Quotane was one-half as toxic as dibucaine. 4. While the intradermal potency of Quotane did not parallel its topical effectiveness it was nevertheless found to be 100 times more active than procaine. 5. Massive doses of Quotane were administered daily to rats and guinea pigs without producing histopathologically demonstrable tissue damage.