TY - JOUR T1 - TOXICOLOGY AND ADDICTION LIABILITY OF MEPERIDINE (DEMEROL) IN EXPERIMENTAL ANIMALS JF - Journal of Pharmacology and Experimental Therapeutics JO - J Pharmacol Exp Ther SP - 147 LP - 152 VL - 103 IS - 2 AU - O. W. Barlow AU - John R. Lewis Y1 - 1951/10/01 UR - http://jpet.aspetjournals.org/content/103/2/147.abstract N2 - Data have been presented of acute toxicity studies of meperidine in frogs' mice, rats, rabbits, cats and dogs. Chronic daily administration of meperidine to rats for sixty days and to rabbits for thirty days produced no deleterious effects. Meperidine was administered orally in single daily doses to dogs and monkeys for a period of ten months. Although certain changes in the animals were observed during the period of medication, no withdrawal symptoms were observed when medication was stopped. Attempts to produce addiction by divided daily doses administered parenterally for shorter periods of time were likewise unsuccessful. ER -