TY - JOUR T1 - DELAYED ARREST OF RAT BRAIN SLICE RESPIRATION CAUSED BY PENTOBARBITAL DURING THE METABOLISM OF GLUCOSE JF - Journal of Pharmacology and Experimental Therapeutics JO - J Pharmacol Exp Ther SP - 1 LP - 6 VL - 103 IS - 1 AU - J. L. Karlsson AU - V. C. Sutherland AU - H. W. Elliott Y1 - 1951/09/01 UR - http://jpet.aspetjournals.org/content/103/1/1.abstract N2 - Oxidation by rat brain slices of glucose, but not of pyruvate, in the presence of a concentration of pentobarbital capable of producing anesthesia in vivo has been shown to result in a delayed but sudden interference with further oxygen uptake. The effect is definitely linked to the metabolism of glucose, since metabolic arrest of the tissue oxidizing pyruvate is obtained a certain length of time after glucose is also added. Extracellular toxicity or exhaustion of metabolites has been ruled out, so that the metabolic arrest must be caused by phenomena inside the tissue. ER -