RT Journal Article
SR Electronic
T1 DELAYED ARREST OF RAT BRAIN SLICE RESPIRATION CAUSED BY PENTOBARBITAL DURING THE METABOLISM OF GLUCOSE
JF Journal of Pharmacology and Experimental Therapeutics
JO J Pharmacol Exp Ther
FD American Society for Pharmacology and Experimental Therapeutics
SP 1
OP 6
VO 103
IS 1
A1 Karlsson, J. L.
A1 Sutherland, V. C.
A1 Elliott, H. W.
YR 1951
UL http://jpet.aspetjournals.org/content/103/1/1.abstract
AB Oxidation by rat brain slices of glucose, but not of pyruvate, in the presence of a concentration of pentobarbital capable of producing anesthesia in vivo has been shown to result in a delayed but sudden interference with further oxygen uptake. The effect is definitely linked to the metabolism of glucose, since metabolic arrest of the tissue oxidizing pyruvate is obtained a certain length of time after glucose is also added. Extracellular toxicity or exhaustion of metabolites has been ruled out, so that the metabolic arrest must be caused by phenomena inside the tissue.