PT  - JOURNAL ARTICLE
AU  - Karlsson, J. L.
AU  - Sutherland, V. C.
AU  - Elliott, H. W.
TI  - DELAYED ARREST OF RAT BRAIN SLICE RESPIRATION CAUSED BY PENTOBARBITAL DURING THE METABOLISM OF GLUCOSE
DP  - 1951 Sep 01
TA  - Journal of Pharmacology and Experimental Therapeutics
PG  - 1--6
VI  - 103
IP  - 1
4099  - http://jpet.aspetjournals.org/content/103/1/1.short
4100  - http://jpet.aspetjournals.org/content/103/1/1.full
SO  - J Pharmacol Exp Ther1951 Sep 01; 103
AB  - Oxidation by rat brain slices of glucose, but not of pyruvate, in the presence of a concentration of pentobarbital capable of producing anesthesia in vivo has been shown to result in a delayed but sudden interference with further oxygen uptake. The effect is definitely linked to the metabolism of glucose, since metabolic arrest of the tissue oxidizing pyruvate is obtained a certain length of time after glucose is also added. Extracellular toxicity or exhaustion of metabolites has been ruled out, so that the metabolic arrest must be caused by phenomena inside the tissue.