RT Journal Article SR Electronic T1 ACUTE TOLERANCE TO THIOPENTAL JF Journal of Pharmacology and Experimental Therapeutics JO J Pharmacol Exp Ther FD American Society for Pharmacology and Experimental Therapeutics SP 215 OP 218 VO 102 IS 4 A1 Brodie, Bernard B. A1 Mark, Lester C. A1 Bernstein, Eleonore A1 Papper, E. M. A1 Lief, Philip A. YR 1951 UL http://jpet.aspetjournals.org/content/102/4/215.abstract AB After a large dose of thiopental, human subjects awake at plasma levels that are considerably higher than those occurring after smaller doses. This tolerance is probably a tissue adaptation to the effects of the drug.