RT Journal Article SR Electronic T1 ACUTE TOLERANCE TO THIOPENTAL JF Journal of Pharmacology and Experimental Therapeutics JO J Pharmacol Exp Ther FD American Society for Pharmacology and Experimental Therapeutics SP 215 OP 218 VO 102 IS 4 A1 Bernard B. Brodie A1 Lester C. Mark A1 Eleonore Bernstein A1 E. M. Papper A1 Philip A. Lief YR 1951 UL http://jpet.aspetjournals.org/content/102/4/215.abstract AB After a large dose of thiopental, human subjects awake at plasma levels that are considerably higher than those occurring after smaller doses. This tolerance is probably a tissue adaptation to the effects of the drug.