TY - JOUR T1 - THE INFLUENCE OF PROCAINE AND SOME RELATED COMPOUNDS UPON EXPERIMENTAL AURICULAR FLUTTER IN THE DOG JF - Journal of Pharmacology and Experimental Therapeutics JO - J Pharmacol Exp Ther SP - 200 LP - 207 VL - 102 IS - 3 AU - Barbara B. Brown AU - George H. Acheson Y1 - 1951/07/01 UR - http://jpet.aspetjournals.org/content/102/3/200.abstract N2 - Auricular flutter was established by the method of Rosenblueth and Garcia Ramos. 1. Stimulation of the vagus or of the sympathetic innervation accelerates flutter. The effects of section of these nerves suggests a tonic discharge in both sets. 2. Diethylaminoethanol (8 to 64 mgm./kgm.) and diethylaminoethyl 2,4-dichlorobenzoate (0.5 to 8 mgm./kgm.) slow both auricular and ventricular rates and often abolish the auricular flutter. These effects are the same in innervated or decentralized hearts. 3. When the innervation has been sectioned, the effects of procaine (0.5 to 8 mgm./kgm.) are like those described in 2. In the presence of intact innervation, however, the auricular deceleration is more marked, the ventricular rate is accelerated, and the incidence of reversion to sinus rhythm is decreased. 4. Procaine blocks the effects of vagal stimulation upon auricular and ventricular rates. This action is absent in the case of diethylaminoethyl 2,4-dichlorobenzoate. ER -