RT Journal Article
SR Electronic
T1 COMBINED ACTION OF CARDIOTOXIC DRUGS: A STUDY ON THE ACUTE TOXICITY OF COMBINED QUINIDINE, MEPERIDINE, PENTOBARBITAL, PROCAINE AND PROCAINE AMIDE
JF Journal of Pharmacology and Experimental Therapeutics
JO J Pharmacol Exp Ther
FD American Society for Pharmacology and Experimental Therapeutics
SP 138
OP 143
VO 102
IS 2
A1 Calesnick, B.
A1 Smith, N. H.
A1 Beutner, R.
YR 1951
UL http://jpet.aspetjournals.org/content/102/2/138.abstract
AB We have demonstrated synergism of acute toxicity when quinidine, meperidine and procaine were used in combination. The possible mode of action has been explored and the potential hazard of cardiotoxicity discussed especially when pentobarbital is also used.