PT - JOURNAL ARTICLE AU - B. Calesnick AU - N. H. Smith AU - R. Beutner TI - COMBINED ACTION OF CARDIOTOXIC DRUGS: A STUDY ON THE ACUTE TOXICITY OF COMBINED QUINIDINE, MEPERIDINE, PENTOBARBITAL, PROCAINE AND PROCAINE AMIDE DP - 1951 Jun 01 TA - Journal of Pharmacology and Experimental Therapeutics PG - 138--143 VI - 102 IP - 2 4099 - http://jpet.aspetjournals.org/content/102/2/138.short 4100 - http://jpet.aspetjournals.org/content/102/2/138.full SO - J Pharmacol Exp Ther1951 Jun 01; 102 AB - We have demonstrated synergism of acute toxicity when quinidine, meperidine and procaine were used in combination. The possible mode of action has been explored and the potential hazard of cardiotoxicity discussed especially when pentobarbital is also used.