RT Journal Article
SR Electronic
T1 STUDY OF DRUG ACTION ON MAMMALIAN CILIATED EPITHELIUM
JF Journal of Pharmacology and Experimental Therapeutics
JO J Pharmacol Exp Ther
FD American Society for Pharmacology and Experimental Therapeutics
SP 132
OP 137
VO 102
IS 2
A1 John V. Scudi
A1 Eugene T. Kimura
A1 John F. Reinhard
YR 1951
UL http://jpet.aspetjournals.org/content/102/2/132.abstract
AB A laboratory method for the quantitative study of drug action on ciliated epithelium has been described. Results obtained with typical vasoconstrictor, antihistaminic and antibacterial drugs are presented. Substances implicated in the allergic state appear to have no direct action on isolated mammalian cilia. A parallelism between cellular irritation and loss of ciliary motility has been observed. It is suggested that changes in membrane permeability lead to the extrusion of viscid globoid bodies which in turn prevent ciliary motion.