TY - JOUR T1 - STUDIES ON THE MECHANISM BY WHICH SULFADIAZINE AFFECTS THE SURVIVAL OF THE MAMMALIAN EMBRYO JF - Journal of Pharmacology and Experimental Therapeutics JO - J Pharmacol Exp Ther SP - 362 LP - 367 VL - 101 IS - 4 AU - Allan D. Bass AU - Chester L. Yntema AU - Warner S. Hammond AU - Marjorie L. Frazer Y1 - 1951/04/01 UR - http://jpet.aspetjournals.org/content/101/4/362.abstract N2 - 1. It has been shown that SAD and SAM reduce the percentage of deliveries when administered to pregnant mice. This effect is obtained when these agents are administered prior to the eighth day of gestation. 2. This effect of sulfadiazine on the pregnancy is not counteracted by nicotinamide or folic acid. 3. Evidence is presented which suggests that high blood concentrations of sulfadiazine interfere in some way with the production or utilization of either the female sex hormones or the gonadotrophic hormones. 4. Lithium chloride and nitrogen mustard also reduce the percentage of deliveries. ER -