PT  - JOURNAL ARTICLE
AU  - Sangeeth, Anjali
AU  - Malleswarapu, Mahesh
AU  - Mishra, Amit
AU  - Gutti, Ravi Kumar
TI  - Long Non-coding RNAs as Cellular Metabolism and Haematopoiesis Regulators
AID  - 10.1124/jpet.121.001120
DP  - 2022 Jan 01
TA  - Journal of Pharmacology and Experimental Therapeutics
PG  - JPET-MR-2022-001120
4099  - http://jpet.aspetjournals.org/content/early/2022/06/06/jpet.121.001120.short
4100  - http://jpet.aspetjournals.org/content/early/2022/06/06/jpet.121.001120.full
AB  - Long non-coding RNAs (lncRNAs) are a category of non-coding RNAs (ncRNAs) which are more than 200 bases long and plays major regulatory roles in a wide range of biological processes including hematopoeisis and metabolism. Metabolism in cells is an immensely complex process that involves the interconnection and unification of numerous signalling pathways. A growing body of affirmation mark that lncRNAs do participate in the metabolism, both directly and indirectly, via metabolic regulation of enzymes and signalling pathway respectively. The complexities are disclosed by the latest studies demonstrating how lncRNAs could indeed alter tissue-specific metabolism? We have entered a new realm for discovery that is both intimidating and intriguing at the same time. Understanding the different functions of lncRNAs in various cellular pathways aids in the advancement of predictive and therapeutic capabilities for a wide variety of myelodysplastic and metabolic disorders. This review has tried to give an overview of the different ncRNAs and their effects on hematopoiesis and metabolism. We have focused on the pathway of action of several lncRNA, and has also delved into their prognostic value. Their use as biomarkers and possible therapeutic targets have also been discussed. Significance Statement -This review gives an overview of the different ncRNAs and their effects on hematopoiesis and metabolism. We have focused on the pathway of action of several lncRNA, and has also delved into their prognostic value. Their use as biomarkers and possible therapeutic targets have also been discussed.