RT Journal Article
SR Electronic
T1 Microglia and Other Myeloid Cells in Central Nervous System Health and Disease
JF Journal of Pharmacology and Experimental Therapeutics
JO J Pharmacol Exp Ther
FD American Society for Pharmacology and Experimental Therapeutics
SP 154
OP 160
DO 10.1124/jpet.120.265058
VO 375
IS 1
A1 Adithya Gopinath
A1 Anthony Collins
A1 Habibeh Khoshbouei
A1 Wolfgang J. Streit
YR 2020
UL http://jpet.aspetjournals.org/content/375/1/154.abstract
AB Mononuclear macrophages derived from the bone marrow (myeloid cells) are key cellular components of the innate immune system in different organs. In this minireview, we are focused on both brain and blood macrophages, known as microglia and monocytes, respectively. We provide a succinct summary of the cells’ functions under both normal and pathologic conditions, with particular reference to common neurodegenerative disorders, such as Alzheimer and Parkinson disease.SIGNIFICANCE STATEMENT In this minireview, we aim to summarize available literature on microglial and myeloid involvement in CNS disease, directing the reader toward relevant and translatable interpretations of myeloid cell function in CNS health and neurodegeneration.