RT Journal Article
SR Electronic
T1 Protein Chimerization: A New Frontier for Engineering Protein Therapeutics with Improved Pharmacokinetics
JF Journal of Pharmacology and Experimental Therapeutics
JO J Pharmacol Exp Ther
FD American Society for Pharmacology and Experimental Therapeutics
SP 703
OP 714
DO 10.1124/jpet.119.257063
VO 370
IS 3
A1 A. R. Satvik Iyengar
A1 Shreya Gupta
A1 Snehal Jawalekar
A1 Abhay H. Pande
YR 2019
UL http://jpet.aspetjournals.org/content/370/3/703.abstract
AB With the advancement of medicine, the utility of protein therapeutics is increasing exponentially. However, a significant number of protein therapeutics suffer from grave limitations, which include their subpar pharmacokinetics. In this study, we have reviewed the emerging field of protein chimerization for improving the short circulatory half-life of protein therapeutics. We have discussed various aspects of protein therapeutics aiming at their mechanism of clearance and various approaches used to increase their short circulatory half-life with principal focus on the concept of chimerization. Furthermore, we have comprehensively reviewed various components of chimera, such as half-life extension partners and linkers, their shortcomings, and prospective work to be undertaken for developing effective chimeric protein therapeutics.