RT Journal Article
SR Electronic
T1 THE MECHANISM OF THE HYPOTENSIVE ACTION OF NARCOTINE HYDROCHLORIDE
JF Journal of Pharmacology and Experimental Therapeutics
JO J Pharmacol Exp Ther
FD American Society for Pharmacology and Experimental Therapeutics
SP 287
OP 295
VO 123
IS 4
A1 Lawrence C. Weaver
A1 William M. Alexander
A1 Benedict E. Abreu
A1 Alice B. Richards
A1 W. Ralph Jones
A1 Robert W. Begley
YR 1958
UL http://jpet.aspetjournals.org/content/123/4/287.abstract
AB Narcotine hydrochloride produces systemic vasodepression which is incompletely blocked by diphenhydramine but is unaffected by atropinization, mid-cervical vagotomy and/or carotid sinus and body denervation. It also increases coronary blood flow and femoral blood flow. Coronary blood flow is increased without significant effects on the other cardiovascular variables. Bronchoconstriction is produced in the dog. Tachyphylaxis develops to the vascular and bronchial effects of this compound. In addition, cross-tachyphylaxis develops between marcotine and 48/80. It is concluded that tue mechanism for these changes is due to histamine liberation.