Data Supplement
- Supplemental Data -
Supplemental Methods and Results
Supplemental Figure 1. Study design for acute hypoxia challenge in telemetered rats.
Supplemental Figure 2. Su/Hx challenge and drug administration in rats.
Supplemental Figure 3. Concentration of TRE in the plasma with IV TRE infusion for 5 weeks.
Supplemental Figure 4. Protein expression associated with extracellular matrix organization.
Supplemental Figure 5. Protein expression associated with 5-hydroxytryptamine degradation
Supplemental Figure 6. Protein expression associated with nictinate/nicotinamide metabolism
Supplemental Table 1. Treatment Group Assignment and Treatment Information.
Supplemental Table 2. Differentially expressed proteins associated with extracellular matrix organization in the right ventricle myocardium of TPIP treated Su/Hx rats) as compared to vehicle treated Su/Hx animals.
Supplemental Table 3. Aldehyde dehydrogenase and retinaldehyde dehydrogenase expression associated with 5-hydroxytryptamine in the right ventricle myocardium of TPIP treated Su/Hx rats as compared to vehicle treated Su/Hx animals.
Supplemental Table 4. Table 4: Nicotinate phosphoribosyltransferase, NAD-dependent protein deacetylase and proton-translocating NAD(P)(+) transhydrogenase expression associated with Nictinate/nicotinamide metabolism in the right ventricle myocardium of TPIP treated Su/Hx rats as compared to vehicle treated Su/Hx animals.
Supplemental References