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OtherDrug Discovery and Translational Medicine

Modulation of Oxidative Phosphorylation with IM156 Attenuates Mitochondrial Metabolic Reprogramming and Inhibits Pulmonary Fibrosis

Robert N. Willette, Parth Mangrolia, Stephen M Pondell, Christopher Young Woo Lee, Sanghee Yoo, Marc S Rudoltz, Benjamin R Cowen and Dean J Welsch
Journal of Pharmacology and Experimental Therapeutics September 30, 2021, JPET-AR-2021-000811; DOI: https://doi.org/10.1124/jpet.121.000811
Robert N. Willette
1R&D, ImmunoMet, United States
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  • For correspondence: bobwillette55@gmail.com
Parth Mangrolia
2R&D, ImmunoMet Therapeutics, United States
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Stephen M Pondell
1R&D, ImmunoMet, United States
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Christopher Young Woo Lee
3R&D, Immunomet, United States
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Sanghee Yoo
3R&D, Immunomet, United States
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Marc S Rudoltz
2R&D, ImmunoMet Therapeutics, United States
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Benjamin R Cowen
2R&D, ImmunoMet Therapeutics, United States
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Dean J Welsch
2R&D, ImmunoMet Therapeutics, United States
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Data Supplement

  • Supplemental Data -

    Supplemental Table 1: Treatment Groups

    Supplemental Table 2: Modified Ashcroft Score

    Supplemental Table 3: Pharmacokinetic Profile of IM156 in Mouse

    Supplemental Table 4: Tissue to Plasma Concentration Ratios for IM156

    Supplemental Figure 1: Rat plasma and tissue concentrations of IM156 were determined in samples obtained approximately 3 hours after the final dose...

    Supplemental Figure 2: AMPK phosphorylation (pT172) was evaluated in cell lysates from an MCF7 cell line (human breast adenocarcinoma) following 24 hours...

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