Data Supplement
- Supplemental Tables -
Supplemental Table S1. LC-MS/MS conditions for the analysis of verinurad and metabolites M1 and M8.
Supplemental Table S2. In vitro evaluation studies of the CYP and UGT inhibition potential of verinurad and metabolites M1 and M8 in human pooled liver microsomes.
Supplemental Table S3. In vitro evaluation studies of the induction potential of verinurad in human primary cultured hepatocytes.
Supplemental Table S4. Transporter substrate studies with verinurad and metabolites M1 and M8 for efflux, renal, and
hepatic uptake transporters.Supplemental Table S5. Transporter inhibition studies with verinurad and metabolites M1 and M8 for efflux, renal, and
hepatic uptake transporters.Supplemental Table S6. Slope analysis of hepatic uptake and percent active uptake in human hepatocytes.
Supplemental Table S7. Induction of cytochrome P450 (CYP) mRNA and activity levels in cultured human hepatocytes... Fold increase relative to vehicle control.
Supplemental Table S8. Induction of cytochrome P450 (CYP) mRNA and activity levels in cultured human hepatocytes... Percent of positive control.