Improved inhibitory and ADMET properties of blebbistatin derivatives indicate that blebbistatin scaffold is ideal for drug development targeting myosin-2

Data Supplement

• Supplemental Data -

  Supplemental methods and results

  Supplementary Figure S1 – Stability of blebbistatin, NBleb and AmBleb in rat blood.

  Supplementary Figure S2 – MS chromatograms of blebbistatin, NBleb and AmBleb, and the major metabolites.

  Supplementary Table S1. Solubility of blebbistatin, NBleb and AmBleb in different buffer conditions.