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OtherDrug Discovery and Translational Medicine

Mechanistic analysis of an ERK2-interacting compound that inhibits mutant-BRAF expressing melanoma cells by inducing oxidative stress

Ramon Martinez, Weiliang Huang, Ramin Samadani, Bryan Mackowiak, Garrick Centola, Lijia Chen, Ivie L Conlon, Kellie Hom, Maureen A. Kane, Steven Fletcher and Paul Shapiro
Journal of Pharmacology and Experimental Therapeutics October 27, 2020, JPET-AR-2020-000266; DOI: https://doi.org/10.1124/jpet.120.000266
Ramon Martinez
1University of Maryland, Baltimore, United States of America
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Weiliang Huang
2Department of Pharmaceutical Sciences, University of Maryland, Baltimore - School of Pharmacy, United States of America
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Ramin Samadani
2Department of Pharmaceutical Sciences, University of Maryland, Baltimore - School of Pharmacy, United States of America
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Bryan Mackowiak
3Pharmaceutical Sciences, University of Maryland School of Pharmacy, United States of America
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Garrick Centola
2Department of Pharmaceutical Sciences, University of Maryland, Baltimore - School of Pharmacy, United States of America
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Lijia Chen
2Department of Pharmaceutical Sciences, University of Maryland, Baltimore - School of Pharmacy, United States of America
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Ivie L Conlon
2Department of Pharmaceutical Sciences, University of Maryland, Baltimore - School of Pharmacy, United States of America
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Kellie Hom
2Department of Pharmaceutical Sciences, University of Maryland, Baltimore - School of Pharmacy, United States of America
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  • ORCID record for Kellie Hom
Maureen A. Kane
2Department of Pharmaceutical Sciences, University of Maryland, Baltimore - School of Pharmacy, United States of America
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Steven Fletcher
2Department of Pharmaceutical Sciences, University of Maryland, Baltimore - School of Pharmacy, United States of America
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Paul Shapiro
4Department of Pharmaceutical Science, University of Maryland, Baltimore - School of Pharmacy, United States of America
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  • For correspondence: pshapiro@rx.umaryland.edu

Data Supplement

  • Supplemental Data -

    Supplemental methods, references, 4 tables, and 7 figures. 

  View article

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