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OtherCardiovascular

KATP Channel Openers Inhibit Lymphatic Contractions and Lymph Flow as a Possible Mechanism of Peripheral Edema

Brittney R. Garner, Amanda J. Stolarz, Daniel Stuckey, Mustafa Sarimollaoglu, Yunmeng Liu, Philip T. Palade, Nancy J. Rusch and Shengyu Mu
Journal of Pharmacology and Experimental Therapeutics October 25, 2020, JPET-AR-2020-000121; DOI: https://doi.org/10.1124/jpet.120.000121
Brittney R. Garner
1Pharmacology & Toxicology, University of Arkansas for Medical Sciences, United States
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Amanda J. Stolarz
2Pharmaceutical Sciences, University of Arkansas for Medical Sciences, United States
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Daniel Stuckey
3Pharmacology and Toxicology, University of Arkansas for Medical Sciences, United States
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Mustafa Sarimollaoglu
4Otolaryngology Laser and Nanomedicine, University of Arkansas for Medical Sciences, United States
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Yunmeng Liu
3Pharmacology and Toxicology, University of Arkansas for Medical Sciences, United States
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Philip T. Palade
3Pharmacology and Toxicology, University of Arkansas for Medical Sciences, United States
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Nancy J. Rusch
5Department of Pharmacology, University of Arkansas, United States of America
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Shengyu Mu
1Pharmacology & Toxicology, University of Arkansas for Medical Sciences, United States
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  • For correspondence: SMu@uams.edu

Data Supplement

  • Supplemental Data -

    Supplementary Table 1 - TaqManTM primers were used to amplify cDNA corresponding to KATP channel subunits in whole rat mesenteric lymph vessels. 

    Supplementary Table 2 - Increasing concentrations of DMSO did not significantly affect rhythmic contractions in isolated rat mesenteric lymph vessels (LVs).

    Supplementary Figure 1 - Glibenclamide partially prevents cromakalim-induced attenuation of rhythmic contractions in isolated rat mesenteric lymph vessels.

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