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Research ArticleDrug Discovery and Translational Medicine

THE ANTI-VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR-1 MONOCLONAL ANTIBODY D16F7 INHIBITS GLIOMA GROWTH AND ANGIOGENESIS IN VIVO

Maria Grazia Atzori, Lucio Tentori, Federica Ruffini, Claudia Ceci, Elena Bonanno, Manuel Scimeca, Pedro Miguel Lacal and Grazia Graziani
Journal of Pharmacology and Experimental Therapeutics October 12, 2017, jpet.117.244434; DOI: https://doi.org/10.1124/jpet.117.244434
Maria Grazia Atzori
1 Department of Systems Medicine, University of Rome Tor Vergata;
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Lucio Tentori
1 Department of Systems Medicine, University of Rome Tor Vergata;
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Federica Ruffini
2 Laboratory of Molecular Oncology, Istituto Dermopatico dell'Immacolata-IRCCS, Rome;
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Claudia Ceci
1 Department of Systems Medicine, University of Rome Tor Vergata;
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Elena Bonanno
3 Department of Experimental Medicine and Surgery, University of Rome Tor Vergata
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Manuel Scimeca
3 Department of Experimental Medicine and Surgery, University of Rome Tor Vergata
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Pedro Miguel Lacal
2 Laboratory of Molecular Oncology, Istituto Dermopatico dell'Immacolata-IRCCS, Rome;
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Grazia Graziani
1 Department of Systems Medicine, University of Rome Tor Vergata;
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Data Supplement

  • Supplemental Figures -


    Figure S1: D16F7 mAb inhibits VEGFR-1 phosphorylation in response to PlGF and VEGF-A in C6-MF3 cells.


    Figure S2: D16F7 mAb specifically recognizes both human and murine VEGFR-1 protein in a concentration-dependent manner.


    Figure S3: Histological analysis of brain sections from long-term surviving mice treated with D16F7.

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