Treatment of skin inflammation with benzoxaborole PDE inhibitors: selectivity, cellular activity, and effect on cytokines associated with skin inflammation and skin architecture changes

Data Supplement

Files in this Data Supplement:

• Supplemental Data -

  Supplemental Figure 1 - Structures of benzoxaborole and catechol PDE4 inhibitors and their IC50s for PDE4B2 catalytic domain

  Supplemental Table 1 - Inhibition of cytokine production from human monocytes, MDDCs and CD4+ T cells

  Supplemental Table 2 - Correlation between suppression of cytokine secretion and PDE4 inhibition

  Supplemental Figure 2 - Compd3 dose-dependently inhibited PMA-induced IL-22 and IL-23 transcription in mouse ears

  Supplemental Figure 3 - Time- and dose-dependent induction of TSLP by calcipotriol in mouse ear skin

  Supplemental Figure 4 - Scheme of the signaling pathways by which a PDE4 inhibitor (PDE4i) suppresses cytokine production in monocytes and T cells