Cynomolgus Monkey as a Potential Model to Assess Drug Interactions Involving Hepatic Organic Anion Transporting Polypeptides (OATPs): In Vitro, In Vivo and In Vitro-to-In Vivo Extrapolation

Data Supplement

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• Supplementary Figures -
  Supplementary Figure 1. Alignment of the predicted amino acid sequences of cynomolgus (Cyno), rhesus (Rhes) and human (Huma) OATPs.
  Supplementary Figure 1B. (OATP1B3).
  Supplementary Figure 1C. (OATP2B1).
  Supplementary Figure 2. Concentration dependent uptake rates (A and B), relative contribution of active and passive processes (C and D), and Eadie-Hofstee plots (E and F) of uptake 3HRSV by cynomolgus monkey and human hepatocytes.
  Supplementary Figure 3. Time course of uptake of 3HRSV (1 μM) by HEK 293 cells stably expressing cOATP (A) and hOATP (B).
  Supplementary Figure 4. Individual AUC0-inf (A), and Cmax values (B) of RSV in 3 cynomolgus monkeys after a single oral dose of 3 mg/kg RSV with and without an oral RIF administration (15 mg/kg).