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Impact of SLC43A3/ENBT1 Expression and Function on 6-Mercaptopurine Transport and Cytotoxicity in Human Acute Lymphoblastic Leukemia Cells
Nicholas M. Ruel, Khanh Hoa Nguyen, Chan S. Kim, Laura P.S. Andrade and James R. Hammond

Journal of Pharmacology and Experimental Therapeutics September 2022, 382 (3) 335-345; DOI: https://doi.org/10.1124/jpet.122.001155
Open Access
Preclinical Characterization of LY3209590, a Novel Weekly Basal Insulin Fc-Fusion Protein
Julie S. Moyers, Ryan J. Hansen, Jonathan W. Day, Craig D. Dickinson, Chen Zhang, Xiaoping Ruan, Liyun Ding, Robin M. Brown, Hana E. Baker and John M. Beals

Journal of Pharmacology and Experimental Therapeutics September 2022, 382 (3) 346-355; DOI: https://doi.org/10.1124/jpet.122.001105
Open Access
Influence of Glutathione-S-Transferase A1*B Allele on the Metabolism of the Aromatase Inhibitor, Exemestane, in Human Liver Cytosols and in Patients Treated With Exemestane
Irina Teslenko, Julia Trudeau, Shaman Luo, Christy J.W. Watson, Gang Chen, Cristina I. Truica and Philip Lazarus

Journal of Pharmacology and Experimental Therapeutics September 2022, 382 (3) 327-334; DOI: https://doi.org/10.1124/jpet.122.001232
Open Access
Intratracheal Administration of Acyl Coenzyme A Acyltransferase-1 Inhibitor K-604 Reduces Pulmonary Inflammation Following Bleomycin-Induced Lung Injury
Emily R. Stevenson, Melissa L. Wilkinson, Elena Abramova, Changjiang Guo and Andrew J. Gow

Journal of Pharmacology and Experimental Therapeutics September 2022, 382 (3) 356-365; DOI: https://doi.org/10.1124/jpet.122.001284
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Peripheral Administration of Selective Glycine Transporter-2 Inhibitor, Oleoyl-_D-Lysine, Reverses Chronic Neuropathic Pain but Not Acute or Inflammatory Pain in Male Mice
Bruce S. Wilson, Julian Peiser-Oliver, Alexander Gillis, Sally Evans, Claudia Alamein, Shannon N. Mostyn, Susan Shimmon, Tristan Rawling, MacDonald J. Christie, Robert J. Vandenberg and Sarasa A. Mohammadi

Journal of Pharmacology and Experimental Therapeutics September 2022, 382 (3) 246-255; DOI: https://doi.org/10.1124/jpet.122.001265
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Effect of Novel Biotherapeutic Elevating Angiopoietin 1 on Progression of Diabetic Nephropathy in Diabetic/Obese Mice
Peng Sun, Christina S. Bartlett, Chao Zheng, Tammy Bigwarfe, Joshuaine M. Grant, Margit MacDougall, Valentina Berger, Steven Kerr, Hu Sheng Qian, Mark McHugh, Hongxing Chen, Xiaomei Zhang, Miranda L. Carpenter, Heather N. Robinson, John Miglietta, Thorsten Lamla and Ryan M. Fryer

Journal of Pharmacology and Experimental Therapeutics September 2022, 382 (3) 266-276; DOI: https://doi.org/10.1124/jpet.121.001067
Open Access
Tralesinidase Alfa Enzyme Replacement Therapy Prevents Disease Manifestations in a Canine Model of Mucopolysaccharidosis Type IIIB
N. Matthew Ellinwood, Bethann N. Valentine, Andrew S. Hess, Jackie K. Jens, Elizabeth M. Snella, Maryam Jamil, Shannon J. Hostetter, Nicholas D. Jeffery, Jodi D. Smith, Suzanne T. Millman, Rebecca L. Parsons, Mark T. Butt, Sundeep Chandra, Martin T. Egeland, Ana B. Assis, Hemanth R. Nelvagal, Jonathan D. Cooper, Igor Nestrasil, Bryon A. Mueller, Rene Labounek, Amy Paulson, Heather Prill, Xiao Ying Liu, Huiyu Zhou, Roger Lawrence, Brett E. Crawford, Anita Grover, Ganesh Cherala, Andrew C. Melton, Anu Cherukuri, Brian R. Vuillemenot, Jill C.M. Wait, Charles A. O’Neill, Jason Pinkstaff, Joseph Kovalchin, Eric Zanelli and Emma McCullagh

Journal of Pharmacology and Experimental Therapeutics September 2022, 382 (3) 277-286; DOI: https://doi.org/10.1124/jpet.122.001119
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Pharmacological Evaluation of a Pegylated Urocortin-1 Peptide in Experimental Autoimmune Disease Models
Josef G. Heuer, Catalina M. Meyer, Hana E. Baker, Andrea Geiser, Jonathan Lucchesi, Daniel Xu, Matthew Hamang, Jennifer A. Martin, Charlie Hu, Kenneth D. Roth, Kannan Thirunavukkarasu, Jorge Alsina-Fernandez and Yanfei L. Ma

Journal of Pharmacology and Experimental Therapeutics September 2022, 382 (3) 287-298; DOI: https://doi.org/10.1124/jpet.122.001151
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Influence of CYP2B6 Pharmacogenetics on Stereoselective Inhibition and Induction of Bupropion Metabolism by Efavirenz in Healthy Volunteers
Brandon T. Gufford, Ingrid F. Metzger, Nadia O. Bamfo, Eric A. Benson, Andrea R. Masters, Jessica Bo Li Lu and Zeruesenay Desta

Journal of Pharmacology and Experimental Therapeutics September 2022, 382 (3) 313-326; DOI: https://doi.org/10.1124/jpet.122.001277
Open Access
Antinociceptive and Analgesic Effects of (2R,6R)-Hydroxynorketamine
Jonathan G. Yost, Hildegard A. Wulf, Caroline A. Browne and Irwin Lucki

Journal of Pharmacology and Experimental Therapeutics September 2022, 382 (3) 256-265; DOI: https://doi.org/10.1124/jpet.122.001278

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