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Methamphetamine Dysregulation of the Central Nervous System and Peripheral Immunity
Douglas R. Miller, Mengfei Bu, Adithya Gopinath, Luis R. Martinez and Habibeh Khoshbouei

Journal of Pharmacology and Experimental Therapeutics December 2021, 379 (3) 372-385; DOI: https://doi.org/10.1124/jpet.121.000767
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5-Aza-4′-thio-2′-deoxycytidine, a New Orally Bioavailable Nontoxic “Best-in-Class”: DNA Methyltransferase 1–Depleting Agent in Clinical Development
William B. Parker and Jaideep V. Thottassery

Journal of Pharmacology and Experimental Therapeutics November 2021, 379 (3) 211-222; DOI: https://doi.org/10.1124/jpet.121.000758
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Therapeutic Effects of Time-Limited Treatment with Brivaracetam on Posttraumatic Epilepsy after Fluid Percussion Injury in the Rat
Clifford L. Eastman, Jason S. Fender, Pavel Klein and Raimondo D’Ambrosio

Journal of Pharmacology and Experimental Therapeutics December 2021, 379 (3) 310-323; DOI: https://doi.org/10.1124/jpet.121.000585
Open Access
Modulation of Oxidative Phosphorylation with IM156 Attenuates Mitochondrial Metabolic Reprogramming and Inhibits Pulmonary Fibrosis
Robert N. Willette, Parth Mangrolia, Stephen M. Pondell, Christopher Young Woo Lee, Sanghee Yoo, Marc S. Rudoltz, Benjamin R. Cowen and Dean J. Welsch

Journal of Pharmacology and Experimental Therapeutics November 2021, 379 (3) 290-300; DOI: https://doi.org/10.1124/jpet.121.000811
Open Access
Deconstructing the Pharmacological Contribution of Sphingosine-1 Phosphate Receptors to Mouse Models of Multiple Sclerosis Using the Species Selectivity of Ozanimod, a Dual Modulator of Human Sphingosine 1-Phosphate Receptor Subtypes 1 and 5
Julie V. Selkirk, Kevin C. Dines, Yingzhuo Grace Yan, Nathan Ching, Deepak Dalvie, Shameek Biswas, Andrea Bortolato, Jeffrey M. Schkeryantz, Carlos Lopez, Iliana Ruiz and Richard Hargreaves

Journal of Pharmacology and Experimental Therapeutics December 2021, 379 (3) 386-399; DOI: https://doi.org/10.1124/jpet.121.000741
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Differential Susceptibilities of Catecholamines to Metabolism by Monoamine Oxidases
David S. Goldstein, Genessis Castillo, Patti Sullivan and Yehonatan Sharabi

Journal of Pharmacology and Experimental Therapeutics November 2021, 379 (3) 253-259; DOI: https://doi.org/10.1124/jpet.121.000826
Open Access
Pharmacokinetics and Pharmacodynamic Effects of Nemvaleukin Alfa, a Selective Agonist of the Intermediate-Affinity IL-2 Receptor, in Cynomolgus Monkeys
Jared E. Lopes, Lei Sun, Heather L. Flick, Erin A. Murphy and Heather C. Losey

Journal of Pharmacology and Experimental Therapeutics November 2021, 379 (2) 203-210; DOI: https://doi.org/10.1124/jpet.121.000612
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A Chemoproteomics Approach to Determine the Mechanism of Testicular Toxicity for the Bruton’s Tyrosine Kinase Inhibitor CC-292
Matt Labenski, Lukas Voortman, Aravind Prasad Medikonda, Philip J. Sherratt and Alan F. Corin

Journal of Pharmacology and Experimental Therapeutics November 2021, 379 (2) 166-174; DOI: https://doi.org/10.1124/jpet.121.000614
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Resolvin Conjugates in Tissue Regeneration 1 Promote Alveolar Fluid Clearance by Activating Alveolar Epithelial Sodium Channels and Na, K-ATPase in Lipopolysaccharide-Induced Acute Lung Injury
Qian Yang, Hao-ran Xu, Shu-yang Xiang, Chen Zhang, Yang Ye, Chen-xi Shen, Hong-xia Mei, Pu-hong Zhang, Hong-yu Ma, Sheng-xing Zheng, Fang-gao Smith, Sheng-wei Jin and Qian Wang

Journal of Pharmacology and Experimental Therapeutics November 2021, 379 (2) 156-165; DOI: https://doi.org/10.1124/jpet.121.000712
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Puerarin Ameliorates 5-Fluorouracil–Induced Intestinal Mucositis in Mice by Inhibiting JAKs
Liang Wang, Baohui Song, Yan Hu, Jun Chen, Shuaishuai Zhang, Dapeng Chen and Jingyu Wang

Journal of Pharmacology and Experimental Therapeutics November 2021, 379 (2) 147-155; DOI: https://doi.org/10.1124/jpet.121.000677

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