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Allosteric Inhibition of the Tumor-Promoting Interaction Between Exon 2–Depleted Splice Variant of Aminoacyl–Transfer RNA Synthetase-Interacting Multifunctional Protein 2 and Heat Shock Protein 70
Dae Gyu Kim, Srigouri Huddar, Semi Lim, Jiwon Kong, Yuno Lee, Chul Min Park, Seungbeom Lee, Young-Ger Suh, Minkyoung Kim, Kyeong Lee, Sunkyung Lee and Sunghoon Kim

Journal of Pharmacology and Experimental Therapeutics December 2021, 379 (3) 358-371; DOI: https://doi.org/10.1124/jpet.121.000766
Open Access
A Monoclonal Anti–Calcitonin Gene-Related Peptide Antibody Decreases Stress-Induced Colonic Hypersensitivity
Ehsan Noor-Mohammadi, Casey Owen Ligon, Kimberly Mackenzie, Jennifer Stratton, Sara Shnider and Beverley Greenwood-Van Meerveld

Journal of Pharmacology and Experimental Therapeutics November 2021, 379 (3) 270-279; DOI: https://doi.org/10.1124/jpet.121.000731
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A Novel Etomidate Analog EL-0052 Retains Potent Hypnotic Effect and Stable Hemodynamics without Suppressing Adrenocortical Function
Xiangqing Xu, Yaqin Wei, Yingying Dong, Yinli Qiu, Zhanbiao Mei, Kai Wang, Jingya Xiu, Tao Wang, Lingguo Zeng, Xiaohu Dong, Yi Shen, Wengao Jiang and Qingeng Li

Journal of Pharmacology and Experimental Therapeutics December 2021, 379 (3) 324-330; DOI: https://doi.org/10.1124/jpet.121.000691
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Glutamate Buffering Capacity and Blood-Brain Barrier Protection of Opioid Receptor Agonists Biphalin and Nociceptin
Saeideh Nozohouri, Yong Zhang, Thamer H. Albekairi, Bhuvaneshwar Vaidya and Thomas J. Abbruscato

Journal of Pharmacology and Experimental Therapeutics November 2021, 379 (3) 260-269; DOI: https://doi.org/10.1124/jpet.121.000831
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Methamphetamine Dysregulation of the Central Nervous System and Peripheral Immunity
Douglas R. Miller, Mengfei Bu, Adithya Gopinath, Luis R. Martinez and Habibeh Khoshbouei

Journal of Pharmacology and Experimental Therapeutics December 2021, 379 (3) 372-385; DOI: https://doi.org/10.1124/jpet.121.000767
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5-Aza-4′-thio-2′-deoxycytidine, a New Orally Bioavailable Nontoxic “Best-in-Class”: DNA Methyltransferase 1–Depleting Agent in Clinical Development
William B. Parker and Jaideep V. Thottassery

Journal of Pharmacology and Experimental Therapeutics November 2021, 379 (3) 211-222; DOI: https://doi.org/10.1124/jpet.121.000758
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Therapeutic Effects of Time-Limited Treatment with Brivaracetam on Posttraumatic Epilepsy after Fluid Percussion Injury in the Rat
Clifford L. Eastman, Jason S. Fender, Pavel Klein and Raimondo D’Ambrosio

Journal of Pharmacology and Experimental Therapeutics December 2021, 379 (3) 310-323; DOI: https://doi.org/10.1124/jpet.121.000585
Open Access
Modulation of Oxidative Phosphorylation with IM156 Attenuates Mitochondrial Metabolic Reprogramming and Inhibits Pulmonary Fibrosis
Robert N. Willette, Parth Mangrolia, Stephen M. Pondell, Christopher Young Woo Lee, Sanghee Yoo, Marc S. Rudoltz, Benjamin R. Cowen and Dean J. Welsch

Journal of Pharmacology and Experimental Therapeutics November 2021, 379 (3) 290-300; DOI: https://doi.org/10.1124/jpet.121.000811
Open Access
Deconstructing the Pharmacological Contribution of Sphingosine-1 Phosphate Receptors to Mouse Models of Multiple Sclerosis Using the Species Selectivity of Ozanimod, a Dual Modulator of Human Sphingosine 1-Phosphate Receptor Subtypes 1 and 5
Julie V. Selkirk, Kevin C. Dines, Yingzhuo Grace Yan, Nathan Ching, Deepak Dalvie, Shameek Biswas, Andrea Bortolato, Jeffrey M. Schkeryantz, Carlos Lopez, Iliana Ruiz and Richard Hargreaves

Journal of Pharmacology and Experimental Therapeutics December 2021, 379 (3) 386-399; DOI: https://doi.org/10.1124/jpet.121.000741
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Differential Susceptibilities of Catecholamines to Metabolism by Monoamine Oxidases
David S. Goldstein, Genessis Castillo, Patti Sullivan and Yehonatan Sharabi

Journal of Pharmacology and Experimental Therapeutics November 2021, 379 (3) 253-259; DOI: https://doi.org/10.1124/jpet.121.000826

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