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Journal of Pharmacology and Experimental Therapeutics

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Latest Articles

  • Allosteric Inhibition of the Tumor-Promoting Interaction Between Exon 2–Depleted Splice Variant of Aminoacyl–Transfer RNA Synthetase-Interacting Multifunctional Protein 2 and Heat Shock Protein 70
    Open Access
    Allosteric Inhibition of the Tumor-Promoting Interaction Between Exon 2–Depleted Splice Variant of Aminoacyl–Transfer RNA Synthetase-Interacting Multifunctional Protein 2 and Heat Shock Protein 70
    Dae Gyu Kim, Srigouri Huddar, Semi Lim, Jiwon Kong, Yuno Lee, Chul Min Park, Seungbeom Lee, Young-Ger Suh, Minkyoung Kim, Kyeong Lee, Sunkyung Lee and Sunghoon Kim
    Journal of Pharmacology and Experimental Therapeutics December 2021, 379 (3) 358-371; DOI: https://doi.org/10.1124/jpet.121.000766
  • Open Access
    A Monoclonal Anti–Calcitonin Gene-Related Peptide Antibody Decreases Stress-Induced Colonic Hypersensitivity
    Ehsan Noor-Mohammadi, Casey Owen Ligon, Kimberly Mackenzie, Jennifer Stratton, Sara Shnider and Beverley Greenwood-Van Meerveld
    Journal of Pharmacology and Experimental Therapeutics November 2021, 379 (3) 270-279; DOI: https://doi.org/10.1124/jpet.121.000731
  • You have access
    A Novel Etomidate Analog EL-0052 Retains Potent Hypnotic Effect and Stable Hemodynamics without Suppressing Adrenocortical Function
    Xiangqing Xu, Yaqin Wei, Yingying Dong, Yinli Qiu, Zhanbiao Mei, Kai Wang, Jingya Xiu, Tao Wang, Lingguo Zeng, Xiaohu Dong, Yi Shen, Wengao Jiang and Qingeng Li
    Journal of Pharmacology and Experimental Therapeutics December 2021, 379 (3) 324-330; DOI: https://doi.org/10.1124/jpet.121.000691
  • You have access
    Glutamate Buffering Capacity and Blood-Brain Barrier Protection of Opioid Receptor Agonists Biphalin and Nociceptin
    Saeideh Nozohouri, Yong Zhang, Thamer H. Albekairi, Bhuvaneshwar Vaidya and Thomas J. Abbruscato
    Journal of Pharmacology and Experimental Therapeutics November 2021, 379 (3) 260-269; DOI: https://doi.org/10.1124/jpet.121.000831
  • You have access
    Methamphetamine Dysregulation of the Central Nervous System and Peripheral Immunity
    Douglas R. Miller, Mengfei Bu, Adithya Gopinath, Luis R. Martinez and Habibeh Khoshbouei
    Journal of Pharmacology and Experimental Therapeutics December 2021, 379 (3) 372-385; DOI: https://doi.org/10.1124/jpet.121.000767
  • You have access
    5-Aza-4′-thio-2′-deoxycytidine, a New Orally Bioavailable Nontoxic “Best-in-Class”: DNA Methyltransferase 1–Depleting Agent in Clinical Development
    William B. Parker and Jaideep V. Thottassery
    Journal of Pharmacology and Experimental Therapeutics November 2021, 379 (3) 211-222; DOI: https://doi.org/10.1124/jpet.121.000758
  • You have access
    Therapeutic Effects of Time-Limited Treatment with Brivaracetam on Posttraumatic Epilepsy after Fluid Percussion Injury in the Rat
    Clifford L. Eastman, Jason S. Fender, Pavel Klein and Raimondo D’Ambrosio
    Journal of Pharmacology and Experimental Therapeutics December 2021, 379 (3) 310-323; DOI: https://doi.org/10.1124/jpet.121.000585
  • Modulation of Oxidative Phosphorylation with IM156 Attenuates Mitochondrial Metabolic Reprogramming and Inhibits Pulmonary Fibrosis
    Open Access
    Modulation of Oxidative Phosphorylation with IM156 Attenuates Mitochondrial Metabolic Reprogramming and Inhibits Pulmonary Fibrosis
    Robert N. Willette, Parth Mangrolia, Stephen M. Pondell, Christopher Young Woo Lee, Sanghee Yoo, Marc S. Rudoltz, Benjamin R. Cowen and Dean J. Welsch
    Journal of Pharmacology and Experimental Therapeutics November 2021, 379 (3) 290-300; DOI: https://doi.org/10.1124/jpet.121.000811
  • Open Access
    Deconstructing the Pharmacological Contribution of Sphingosine-1 Phosphate Receptors to Mouse Models of Multiple Sclerosis Using the Species Selectivity of Ozanimod, a Dual Modulator of Human Sphingosine 1-Phosphate Receptor Subtypes 1 and 5
    Julie V. Selkirk, Kevin C. Dines, Yingzhuo Grace Yan, Nathan Ching, Deepak Dalvie, Shameek Biswas, Andrea Bortolato, Jeffrey M. Schkeryantz, Carlos Lopez, Iliana Ruiz and Richard Hargreaves
    Journal of Pharmacology and Experimental Therapeutics December 2021, 379 (3) 386-399; DOI: https://doi.org/10.1124/jpet.121.000741
  • Differential Susceptibilities of Catecholamines to Metabolism by Monoamine Oxidases
    You have access
    Differential Susceptibilities of Catecholamines to Metabolism by Monoamine Oxidases
    David S. Goldstein, Genessis Castillo, Patti Sullivan and Yehonatan Sharabi
    Journal of Pharmacology and Experimental Therapeutics November 2021, 379 (3) 253-259; DOI: https://doi.org/10.1124/jpet.121.000826

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ISSN 1521-0103 (Online)

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