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Botulinum Toxin A, a Better Choice for Skeletal Muscle Block in a Comparative Study With Lidocaine in Rats
Ke Xu, Zhan Zhang, Yueying Li, Lili Song, Jin Gou, Chengkuan Sun, Jiayang Li, Shuang Du, Rangjuan Cao and Shusen Cui

Journal of Pharmacology and Experimental Therapeutics December 2022, 383 (3) 227-237; DOI: https://doi.org/10.1124/jpet.122.001313
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A Physiologically-Based Pharmacokinetic Model of the Brain Considering Regional Lipid Variance
Andrew McPherson Heitman, Robert R. Bies and Sorell L. Schwartz

Journal of Pharmacology and Experimental Therapeutics December 2022, 383 (3) 217-226; DOI: https://doi.org/10.1124/jpet.122.001256
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Pharmacodynamic and Antitumor Activity of BI 836880, a Dual VEGF and Angiopoietin 2 Inhibitor, Alone and Combined with Programmed Cell Death Protein-1 Inhibition
Irmgard Hofmann, Anke Baum, Marco H. Hofmann, Francesca Trapani, Claudia Reichel-Voda, Diane Ehrensperger, Martin Aichinger, Florian Ebner, Nicole Budano, Norbert Schweifer, Martina Sykora, Erik Depla, Joachim Boucneau, Andreas Gschwind, Norbert Kraut, Frank Hilberg and Klaus-Peter Künkele

Journal of Pharmacology and Experimental Therapeutics October 14, 2022, JPET-AR-2022-001255; DOI: https://doi.org/10.1124/jpet.122.001255
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Activation of GPR183 by 7α,25-Dihydroxycholesterol Induces Behavioral Hypersensitivity through Mitogen-Activated Protein Kinase and Nuclear Factor-κB
Kathryn Braden, Michela Campolo, Ying Li, Zhoumou Chen, Timothy M. Doyle, Luigino Antonio Giancotti, Emanuela Esposito, Jinsong Zhang, Salvatore Cuzzocrea, Christopher Kent Arnatt and Daniela Salvemini

Journal of Pharmacology and Experimental Therapeutics November 2022, 383 (2) 172-181; DOI: https://doi.org/10.1124/jpet.122.001283
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Metabotropic Glutamate Receptors Modulate Exocytotic Tau Release and Propagation
Francesca Mazzo, Ioana Butnaru, Olivera Grubisha, Elena Ficulle, Helen Sanger, Griffin Fitzgerald, Feng Pan, Francesca Pasqui, Tracey Murray, James Monn, Xia Li, Michael Hutton, Suchira Bose, Giampietro Schiavo and Emanuele Sher

Journal of Pharmacology and Experimental Therapeutics November 2022, 383 (2) 117-128; DOI: https://doi.org/10.1124/jpet.122.001307
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Differential Activation and Desensitization States Promoted by Noncanonical α7 Nicotinic Acetylcholine Receptor Agonists
Clare Stokes, Gisela Andrea Camacho-Hernandez, Ganesh A. Thakur, Xiaoxuan Wu, Palmer Taylor and Roger L. Papke

Journal of Pharmacology and Experimental Therapeutics November 2022, 383 (2) 157-171; DOI: https://doi.org/10.1124/jpet.122.001354
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A Novel Truncated Liver Enriched Antimicrobial Peptide-2 Palmitoylated at its N-Terminal Antagonizes Effects of Ghrelin
Lucie Holá, Blanka Železná, Alena Karnošová, Jaroslav Kuneš, Jean-Alain Fehrentz, Séverine Denoyelle, Sonia Cantel, Miroslava Blechová, David Sýkora, Aneta Myšková and Lenka Maletínská

Journal of Pharmacology and Experimental Therapeutics November 2022, 383 (2) 129-136; DOI: https://doi.org/10.1124/jpet.122.001322
Open Access
Mitochondrial Dysfunction and Pharmacodynamics of Mitofusin Activation in Murine Charcot-Marie-Tooth Disease Type 2A
Antonietta Franco, Xiawei Dang, Lihong Zhang, Perry B. Molinoff and Gerald W. Dorn

Journal of Pharmacology and Experimental Therapeutics November 2022, 383 (2) 137-148; DOI: https://doi.org/10.1124/jpet.122.001332
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Is Diminazene an Angiotensin-Converting Enzyme 2 (ACE2) Activator? Experimental Evidence and Implications
Shiva Hadi Esfahani, Srinidhi Jayaraman and Vardan T. Karamyan

Journal of Pharmacology and Experimental Therapeutics November 2022, 383 (2) 149-156; DOI: https://doi.org/10.1124/jpet.122.001339
Open Access
Plasma and Liver Pharmacokinetics of the N-Acetylgalactosamine Short Interfering RNA JNJ-73763989 in Recombinant Adeno-Associated–Hepatitis B Virus–Infected Mice
Louis Sandra, Huybrecht T’jollyn, Nele Goeyvaerts, An Vermeulen, Anne-Gaëlle Dosne and Juan-Jose Perez-Ruixo

Journal of Pharmacology and Experimental Therapeutics October 2022, 383 (1) 70-79; DOI: https://doi.org/10.1124/jpet.122.001229

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