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Central Nervous System Distribution of an Opioid Agonist Combination with Synergistic Activity
Jessica I. Griffith, Minjee Kim, Daniel J. Bruce, Cristina D. Peterson, Kelley F. Kitto, Afroz S. Mohammad, Sneha Rathi, Carolyn A. Fairbanks, George L. Wilcox and William F. Elmquist

Journal of Pharmacology and Experimental Therapeutics January 2022, 380 (1) 34-46; DOI: https://doi.org/10.1124/jpet.121.000821
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Ixazomib Induces Apoptosis and Suppresses Proliferation in Esophageal Squamous Cell Carcinoma through Activation of the c-Myc/NOXA Pathway
Tianxiao Wang, Pengying Zhang, Lu Chen, Huijie Qi, Haifei Chen, Yongjun Zhu, Liudi Zhang, Mingkang Zhong, Xiaojin Shi and Qunyi Li

Journal of Pharmacology and Experimental Therapeutics January 2022, 380 (1) 15-25; DOI: https://doi.org/10.1124/jpet.121.000837
Open Access
Thiabendazole Inhibits Glioblastoma Cell Proliferation and Invasion Targeting Mini-chromosome Maintenance Protein 2
Yaotian Hu, Wenjing Zhou, Zhiyi Xue, Xuemeng Liu, Zichao Feng, Yulin Zhang, Xiaofei Liu, Wenjie Li, Qing Zhang, Anjing Chen, Bin Huang and Jian Wang

Journal of Pharmacology and Experimental Therapeutics January 2022, 380 (1) 63-75; DOI: https://doi.org/10.1124/jpet.121.000852
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The Role of Ruthenium Compounds in Neurologic Diseases: A Minireview
Fátima Virgínia Gama Justi, Gabriella Araújo Matos, Juan de Sá Roriz Caminha, Cássia Rodrigues Roque, Edinilton Muniz Carvalho, Márcio Wilker Soares Campelo, Ludmila Belayev, Luiz Gonzaga de França Lopes and Reinaldo Barreto Oriá

Journal of Pharmacology and Experimental Therapeutics January 2022, 380 (1) 47-53; DOI: https://doi.org/10.1124/jpet.121.000798
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ASP7266, a Novel Antibody against Human Thymic Stromal Lymphopoietin Receptor for the Treatment of Allergic Diseases
Mako Numazaki, Masaki Abe, Kaori Hanaoka, Emiko Imamura, Masashi Maeda, Akihiko Kimura, Jun Miyanohara, Tetsu Saito, Kazunori Arai, Hiroshi Suzuki and Yuji Saita

Journal of Pharmacology and Experimental Therapeutics January 2022, 380 (1) 26-33; DOI: https://doi.org/10.1124/jpet.121.000686
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The Cannabinoid Receptor Type 1 Positive Allosteric Modulator ZCZ011 Attenuates Naloxone-Precipitated Diarrhea and Weight Loss in Oxycodone-Dependent Mice
Julien C. Dodu, Rebecca K. Moncayo, M. Imad Damaj, Joel E. Schlosburg, Hamid I. Akbarali, Lesley D. O’Brien, Debra A. Kendall, Zhixing Wu, Dai Lu and Aron H. Lichtman

Journal of Pharmacology and Experimental Therapeutics January 2022, 380 (1) 1-14; DOI: https://doi.org/10.1124/jpet.121.000723
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Novel Platform for Predicting Drug Effects in Patients with Acromegaly: Translational Exposure-Response Evaluation of Growth Hormone–Inhibitory Effect of Octreotide after Growth Hormone–Releasing Hormone Stimulation
Hiroyuki Iida, Tatsuya Komagata, Hirotaka Tanaka, Ryusuke Nagasawa, Takuya Nishio, Tomoyuki Shono, Junsaku Kitagawa, Ken-ichi Ogawara, Koji Shinozaki, Akiteru Seki, Mark Bruce and Tomoya Ohno

Journal of Pharmacology and Experimental Therapeutics December 2021, 379 (3) 400-408; DOI: https://doi.org/10.1124/jpet.121.000769
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5-Aza-4′-thio-2′-deoxycytidine, a New Orally Bioavailable Nontoxic “Best-in-Class”: DNA Methyltransferase 1–Depleting Agent in Clinical Development
William B. Parker and Jaideep V. Thottassery

Journal of Pharmacology and Experimental Therapeutics November 2021, 379 (3) 211-222; DOI: https://doi.org/10.1124/jpet.121.000758
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Therapeutic Effects of Time-Limited Treatment with Brivaracetam on Posttraumatic Epilepsy after Fluid Percussion Injury in the Rat
Clifford L. Eastman, Jason S. Fender, Pavel Klein and Raimondo D’Ambrosio

Journal of Pharmacology and Experimental Therapeutics December 2021, 379 (3) 310-323; DOI: https://doi.org/10.1124/jpet.121.000585
Open Access
Modulation of Oxidative Phosphorylation with IM156 Attenuates Mitochondrial Metabolic Reprogramming and Inhibits Pulmonary Fibrosis
Robert N. Willette, Parth Mangrolia, Stephen M. Pondell, Christopher Young Woo Lee, Sanghee Yoo, Marc S. Rudoltz, Benjamin R. Cowen and Dean J. Welsch

Journal of Pharmacology and Experimental Therapeutics November 2021, 379 (3) 290-300; DOI: https://doi.org/10.1124/jpet.121.000811

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