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Viral Proteases as Targets for Coronavirus Disease 2019 Drug Development
Wei Zhu, Zeenat Shyr, Donald C. Lo and Wei Zheng

Journal of Pharmacology and Experimental Therapeutics August 2021, 378 (2) 166-172; DOI: https://doi.org/10.1124/jpet.121.000688
Open Access
Liver-Specific Nonviral Gene Delivery of Fibroblast Growth Factor 21 Protein Expression in Mice Regulates Body Mass and White/Brown Fat Respiration
Nathaniel G. Girer, Victoria G. Rontoyanni, Aditya Joshi, Igor Patrikeev, Andrew J. Murton, Craig Porter, Massoud Motamedi and Cornelis J. Elferink

Journal of Pharmacology and Experimental Therapeutics August 2021, 378 (2) 157-165; DOI: https://doi.org/10.1124/jpet.121.000514
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A Comparison of Breathing Stimulants for Reversal of Synthetic Opioid-Induced Respiratory Depression in Conscious Rats
Kaye E. Dandrea and Joseph F. Cotten

Journal of Pharmacology and Experimental Therapeutics August 2021, 378 (2) 146-156; DOI: https://doi.org/10.1124/jpet.121.000675
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RCTR1 promotes alveolar fluid clearance by activating alveolar epithelial sodium channels and Na, K-ATPase in LPS-induced acute lung injury
Qian Yang, Hao-ran Xu, Shu-yang Xiang, Chen Zhang, Yang Ye, Chen-xi Shen, Hong-xia Mei, Pu-hong Zhang, Hong-yu Ma, Sheng-xing Zheng, Fang-gao Smith, Sheng-wei Jin and Qian Wang

Journal of Pharmacology and Experimental Therapeutics August 31, 2021, JPET-AR-2021-000712; DOI: https://doi.org/10.1124/jpet.121.000712
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A Novel Maintenance Therapeutic for Opioid Use Disorder
Beth Youngblood, Kevin Li, Donald R. Gehlert, Julio C. Medina and Neil Schwartz

Journal of Pharmacology and Experimental Therapeutics August 2021, 378 (2) 133-145; DOI: https://doi.org/10.1124/jpet.120.000214
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Semi-Mechanistic Modeling of the Effects of Blast Overpressure Exposure on Cefazolin Pharmacokinetics in Mice
Daniel J. Selig, Geoffrey C. Chin, Alexander G. Bobrov, Jesse P. DeLuca, Derese Getnet, Jeffrey R. Livezey, Joseph B. Long, Venkatasivasai S. Sajja, Brett E. Swierczewski, Stuart D. Tyner and Vlado Antonic

Journal of Pharmacology and Experimental Therapeutics August 25, 2021, JPET-AR-2021-000797; DOI: https://doi.org/10.1124/jpet.121.000797
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Influence of contingent and noncontingent drug histories on the development of high levels of MDPV self-administration
Michelle R. Doyle, Agnieszka Sulima, Kenner C Rice and Gregory T. Collins

Journal of Pharmacology and Experimental Therapeutics August 19, 2021, JPET-AR-2021-000655; DOI: https://doi.org/10.1124/jpet.121.000655
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Minimal physiologically based pharmacokinetic-pharmacodynamic (mPBPK-PD) model of GalNAc-conjugated siRNA disposition and gene silencing in preclinical species and humans
Vivaswath S Ayyar, Dawei Song, Songmao Zheng, Thomas Carpenter and Donald L Heald

Journal of Pharmacology and Experimental Therapeutics August 19, 2021, JPET-AR-2021-000805; DOI: https://doi.org/10.1124/jpet.121.000805
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The Small Molecule BC-2059 Inhibits Wingless/Integrated (Wnt)-Dependent Gene Transcription in Cancer through Disruption of the Transducin β-Like 1-β-Catenin Protein Complex
Raffaella Soldi, Tithi Ghosh Halder, Samuel Sampson, Hariprasad Vankayalapati, Alexis Weston, Trason Thode, Kapil N. Bhalla, Serina Ng, Ryan Rodriguez del Villar, Kevin Drenner, Mohan R. Kaadige, Stephen K. Horrigan, Surinder K. Batra, Ravi Salgia and Sunil Sharma

Journal of Pharmacology and Experimental Therapeutics August 2021, 378 (2) 77-86; DOI: https://doi.org/10.1124/jpet.121.000634
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MC-100093, a Novel β-Lactam Glutamate Transporter-1 Enhancer Devoid of Antimicrobial Properties, Attenuates Cocaine Relapse in Rats
Lori A. Knackstedt, Lizhen Wu, Jeffrey Rothstein, Svetlana Vidensky, John Gordon, Mercy Ramanjulu, Paul Dunman, Benjamin Blass, Wayne Childers and Magid Abou-Gharbia

Journal of Pharmacology and Experimental Therapeutics August 2021, 378 (2) 51-59; DOI: https://doi.org/10.1124/jpet.121.000532

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