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CARDIAC ANTHRACYCLINE ACCUMULATION AND B-TYPE NATRIURETIC PEPTIDE TO DEFINE RISK AND PREDICTORS OF CANCER TREATMENT RELATED EARLY DIASTOLIC DYSFUNCTION
Giorgio Minotti, Emanuela Salvatorelli, Giorgio Reggiardo, Fabio Mangiacapra, Massimiliano Camilli and Pierantonio Menna

Journal of Pharmacology and Experimental Therapeutics March 24, 2022, JPET-AR-2022-001101; DOI: https://doi.org/10.1124/jpet.122.001101
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Neutrophil-derived Myeloperoxidase and Hypochlorous Acid Critically Contribute to 20-HETE Increases that Drive Post-Ischemic Angiogenesis
Juan A Azcona, Samantha Tang, Elizabeth Berry, Frank F Zhang, Radha Garvey, John R Falck, Michal Laniado Schwartzman, Tao Yi, Thomas M Jeitner and Austin M Guo

Journal of Pharmacology and Experimental Therapeutics March 19, 2022, JPET-AR-2021-001036; DOI: https://doi.org/10.1124/jpet.121.001036
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The Andrographolide Analogue 3A.1 Synergizes with Taxane Derivatives in Aggressive Metastatic Prostate Cancers by Upregulation of Heat Shock Proteins and Downregulation of MAT2A-Mediated Cell Migration and Invasion
Taraswi Mitra Ghosh, Teeratas Kansom, Suman Mazumder, Joshua Davis, Ahmed S. Alnaim, Shanese L. Jasper, Chu Zhang, Aedan Bird, Praneet Opanasopit, Amit K. Mitra and Robert D. Arnold

Journal of Pharmacology and Experimental Therapeutics March 2022, 380 (3) 180-201; DOI: https://doi.org/10.1124/jpet.121.000898
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A Potent Inhibitor of Aminopeptidase P2 Reduces Reperfusion Injury in Models of Myocardial Infarction and Stroke
Morgan R. Lenz, Shih-Yen Tsai, Anne E. Roessler, Yang Wang, Periannan Sethupathi, W. Keith Jones, Gwendolyn L. Kartje and William H. Simmons

Journal of Pharmacology and Experimental Therapeutics March 2022, 380 (3) 220-229; DOI: https://doi.org/10.1124/jpet.121.000875
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Etavopivat, a Pyruvate Kinase Activator in Red Blood Cells, for the Treatment of Sickle Cell Disease
Patricia Schroeder, Keertik Fulzele, Sanjeev Forsyth, Maria D. Ribadeneira, Sylvie Guichard, Erik Wilker, C. Gary Marshall, Adam Drake, Rose Fessler, Diamantis G. Konstantinidis, Katie G. Seu and Theodosia A. Kalfa

Journal of Pharmacology and Experimental Therapeutics March 2022, 380 (3) 210-219; DOI: https://doi.org/10.1124/jpet.121.000743
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Empagliflozin Protects against Pulmonary Ischemia/Reperfusion Injury via an Extracellular Signal-Regulated Kinases 1 and 2-Dependent Mechanism
Dou Huang, Feng Ju, Lei Du, Ting Liu, Yunxia Zuo, Geoffrey W. Abbott and Zhaoyang Hu

Journal of Pharmacology and Experimental Therapeutics March 2022, 380 (3) 230-241; DOI: https://doi.org/10.1124/jpet.121.000956
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The Skeletal Muscle Relaxer Cyclobenzaprine Is a Potent Non-Competitive Antagonist of Histamine H1 Receptors
Kirti Singh, Ilya S. Senatorov, Ameneh Cheshmehkani, Priyanka F. Karmokar and Nader H. Moniri

Journal of Pharmacology and Experimental Therapeutics March 2022, 380 (3) 202-209; DOI: https://doi.org/10.1124/jpet.121.000998
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Characterization of the Discriminative Stimulus Effects of Binary Mixtures of Mu Opioid Receptor Agonists in Rats Discriminating Fentanyl
Shawn M. Flynn and Charles P. France

Journal of Pharmacology and Experimental Therapeutics March 2022, 380 (3) 171-179; DOI: https://doi.org/10.1124/jpet.121.000912
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RTICBM-74 Is a Brain-Penetrant Cannabinoid Receptor Subtype 1 Allosteric Modulator that Reduces Alcohol Intake in Rats
Dennis F. Lovelock, Thuy Nguyen, Kalynn Van Voorhies, Yanan Zhang and Joyce Besheer

Journal of Pharmacology and Experimental Therapeutics March 2022, 380 (3) 153-161; DOI: https://doi.org/10.1124/jpet.121.000919
Open Access
The Dopamine D1 Receptor Positive Allosteric Modulator Mevidalen (LY3154207) Enhances Wakefulness in the Humanized D1 Mouse and in Sleep-Deprived Healthy Male Volunteers
Andrew P. McCarthy, Kjell A. Svensson, Elaine Shanks, Claire Brittain, Brian J. Eastwood, William Kielbasa, Kevin M. Biglan and Keith A. Wafford

Journal of Pharmacology and Experimental Therapeutics March 2022, 380 (3) 143-152; DOI: https://doi.org/10.1124/jpet.121.000719

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