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Deconstructing the Pharmacological Contribution of Sphingosine-1 Phosphate Receptors to Mouse Models of Multiple Sclerosis Using the Species Selectivity of Ozanimod, a Dual Modulator of Human Sphingosine-1 Phosphate Receptor Subtypes 1 and 5
Julie V. Selkirk, Kevin C. Dines, Yingzhuo Grace Yan, Nathan Ching, Deepak Dalvie, Shameek Biswas, Andrea Bortolato, Jeffrey M. Schkeryantz, Carlos Lopez, Iliana Ruiz and Richard Hargreaves

Journal of Pharmacology and Experimental Therapeutics September 17, 2021, JPET-AR-2021-000741; DOI: https://doi.org/10.1124/jpet.121.000741
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Cardiac effects of novel histamine H₂ receptor agonists
Ulrich Gergs, Maren L. Büxel, Merlin Bresinsky, Uwe Kirchhefer, Charlotte Fehse, Carina Höring, Britt Hofmann, Margareta Marusakova, Aneta Čináková, Rebecca Schwarz, Steffen Pockes and Joachim Neumann

Journal of Pharmacology and Experimental Therapeutics September 17, 2021, JPET-AR-2021-000822; DOI: https://doi.org/10.1124/jpet.121.000822
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Methamphetamine dysregulation of the central nervous system and peripheral immunity
Douglas R. Miller, Anthea-Mengfei Bu, Adithya Gopinath, Luis R. Martinez and Habibeh Khoshbouei

Journal of Pharmacology and Experimental Therapeutics September 17, 2021, JPET-MR-2021-000767; DOI: https://doi.org/10.1124/jpet.121.000767
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Selective acetyl-CoA carboxylase 1 inhibitor improves hepatic steatosis and hepatic fibrosis in a pre-clinical NASH model
Yumiko Okano Tamura, Jun Sugama, Shinji Iwasaki, Masako Sasaki, Hironobu Yasuno, Kazunobu Aoyama, Masanori Watanabe, Derek M Erion and Hiroaki Yashiro

Journal of Pharmacology and Experimental Therapeutics September 17, 2021, JPET-AR-2021-000786; DOI: https://doi.org/10.1124/jpet.121.000786
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Small-Molecule Integrated Stress Response Inhibitor Reduces Susceptibility to Postinfarct Atrial Fibrillation in Rats via the Inhibition of Integrated Stress Responses
Ting Zhang, Yong Wu, Zhengtao Hu, Wen Xing, LV Kun, Deguo Wang and Nengwei Hu

Journal of Pharmacology and Experimental Therapeutics September 2021, 378 (3) 197-206; DOI: https://doi.org/10.1124/jpet.121.000491
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Nose-to-Brain Delivery of Dexamethasone: Biodistribution Studies in Mice
Iván Nicolás Pérez-Osorio, Alejandro Espinosa, Manuel Giraldo Velázquez, Patricia Padilla, Brandon Bárcena, Gladis Fragoso, Helgi Jung-Cook, Hugo Besedovsky, Gabriela Meneses and Edda Lydia Sciutto Conde

Journal of Pharmacology and Experimental Therapeutics September 2021, 378 (3) 244-250; DOI: https://doi.org/10.1124/jpet.121.000530
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A Novel Selective PKR Inhibitor Restores Cognitive Deficits and Neurodegeneration in Alzheimer Disease Experimental Models
Matilde Lopez-Grancha, Patrick Bernardelli, Nicolas Moindrot, Elisabeth Genet, Carine Vincent, Valerie Roudieres, AIain Krick, Jean-François Sabuco, David Machnik, Delphine Ibghi, Laurent Pradier and Veronique Taupin

Journal of Pharmacology and Experimental Therapeutics September 2021, 378 (3) 262-275; DOI: https://doi.org/10.1124/jpet.121.000590
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The Soluble (Pro)Renin Receptor in Health and Diseases: Foe or Friend?
Manman Qin, Chuanming Xu and Jun Yu

Journal of Pharmacology and Experimental Therapeutics September 2021, 378 (3) 251-261; DOI: https://doi.org/10.1124/jpet.121.000576
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Persistent Exposure to Δ⁹-Tetrahydrocannabinol during Adolescence Does Not Affect Nociceptive Responding in Adult Mice
Alex Mabou Tagne, Yannick Fotio, Tarif Ibne Rashid and Daniele Piomelli

Journal of Pharmacology and Experimental Therapeutics September 2021, 378 (3) 215-221; DOI: https://doi.org/10.1124/jpet.121.000740
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P300 Participates in Ionizing Radiation–Mediated Activation of Cathepsin L by Mutant p53
Ya-jie Xiong, Ying Zhu, Ya-li Liu, Yi-fan Zhao, Xiao Shen, Wen-qing Zuo, Fang Lin and Zhong-qin Liang

Journal of Pharmacology and Experimental Therapeutics September 2021, 378 (3) 276-286; DOI: https://doi.org/10.1124/jpet.121.000639

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