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Anisodamine enhances macrophage M2 polarization through suppressing G9a-mediated IRF4 silencing to alleviate LPS-induced acute lung injury
Yunfeng Zhang, Dingli Song, Ziyang Peng, Rui Wang, Kai Li, Hong Ren, Xin Sun, Ning Du and Shou-Ching Tang

Journal of Pharmacology and Experimental Therapeutics April 5, 2022, JPET-AR-2021-001019; DOI: https://doi.org/10.1124/jpet.121.001019
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CNS delivery of the DNA-PK_cs inhibitor peposertib as radiosensitizer for brain metastases
Surabhi Talele, Wenjuan Zhang, Ju-Hee Oh, Danielle M. Burgenske, Ann C Mladek, Sonja Dragojevic, Jann N. Sarkaria and William F. Elmquist

Journal of Pharmacology and Experimental Therapeutics April 3, 2022, JPET-AR-2021-001069; DOI: https://doi.org/10.1124/jpet.121.001069
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Cinnabarinic Acid-Induced Stanniocalcin 2 Confers Cytoprotection against Alcohol-Induced Liver Injury
Aditya D. Joshi, Gopal Thinakaran and Cornelis Elferink

Journal of Pharmacology and Experimental Therapeutics April 2022, 381 (1) 1-11; DOI: https://doi.org/10.1124/jpet.121.000999
Open Access
A Phase I, First-in-Human, Healthy Volunteer Study to Investigate the Safety, Tolerability, and Pharmacokinetics of CVN424, a Novel G Protein-Coupled Receptor 6 Inverse Agonist for Parkinson’s Disease
David H. Margolin, Nicola L. Brice, Antonia M. Davidson, Kim L. Matthews and Mark B. L. Carlton

Journal of Pharmacology and Experimental Therapeutics April 2022, 381 (1) 33-41; DOI: https://doi.org/10.1124/jpet.121.000842
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Attenuation of Response to Repeated Drug Administration: A Proposal for Differentiating Tachyphylaxis and Tolerance
Craig K. Svensson

Journal of Pharmacology and Experimental Therapeutics April 2022, 381 (1) 22-32; DOI: https://doi.org/10.1124/jpet.121.000978
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Inhibition of Colon Cancer Cell Growth by Phosphodiesterase Inhibitors Is Independent of cGMP Signaling
Yali Hou, Alexis Wren, Namratha Mylarapu, Kaylin Browning, Bianca N. Islam, Rui Wang, Kenneth J. Vega and Darren D. Browning

Journal of Pharmacology and Experimental Therapeutics April 2022, 381 (1) 42-53; DOI: https://doi.org/10.1124/jpet.121.001075
Open Access
Preclinical Immunopharmacologic Assessment of KPL-404, a Novel, Humanized, Non-Depleting Antagonistic Anti-CD40 Monoclonal Antibody
Sujatha Muralidharan, Moses Njenga, Tracy Garron, Kent Bondensgaard and John F. Paolini

Journal of Pharmacology and Experimental Therapeutics April 2022, 381 (1) 12-21; DOI: https://doi.org/10.1124/jpet.121.000881
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Anesthetic preconditioning of traumatic brain injury is ineffective in a Drosophila model of obesity
Dena Johnson-Schlitz, Julie A Fischer, Hannah J Schiffman, Amanda R Scharenbrock, Zachariah PG Olufs, David A Wassarman and Misha Perouansky

Journal of Pharmacology and Experimental Therapeutics March 28, 2022, JPET-AR-2021-000997; DOI: https://doi.org/10.1124/jpet.121.000997
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ACE2 inhibits lipopolysaccharide-caused lung fibrosis via downregulating the TGF-β1/Smad2/Smad3 pathway
Xingsheng Lin, Wenhao Lin, Yingfeng Zhuang and Fengying Gao

Journal of Pharmacology and Experimental Therapeutics March 28, 2022, JPET-AR-2021-000907; DOI: https://doi.org/10.1124/jpet.121.000907
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L-Arginine Enhances the Effects of Cardiac Rehabilitation on Physical Performance: New Insights for Managing Cardiovascular Patients During the COVID-19 Pandemic
Pasquale Mone, Raffaele Izzo, Giuseppe Marazzi, Maria Virginia Manzi, Paola Gallo, Giuseppe Campolongo, Luca Cacciotti, Domenico Tartaglia, Giuseppe Caminiti, Fahimeh Varzideh, Gaetano Santulli and Valentina Trimarco

Journal of Pharmacology and Experimental Therapeutics March 26, 2022, JPET-AR-2022-001149; DOI: https://doi.org/10.1124/jpet.122.001149

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