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Therapeutic Basis of Generic Substitution of Antiseizure Medications
Sarah Elmer and Doodipala Samba Reddy

Journal of Pharmacology and Experimental Therapeutics May 2022, 381 (2) 188-196; DOI: https://doi.org/10.1124/jpet.121.000994
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Sodium pentobarbital suppresses breast cancer cells growth partly via normalizing microcirculatory hemodynamics and oxygenation in tumors
Qin Wang, Xueting Liu, Bingwei Li, Xiaojie Yang, Wenbao Lu, Ailing Li, Hongwei Li, Xiaoyan Zhang and Jianqun Han

Journal of Pharmacology and Experimental Therapeutics May 5, 2022, JPET-AR-2021-001058; DOI: https://doi.org/10.1124/jpet.121.001058
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Optimized S-nitrosohemoglobin synthesis in red blood cells to preserve hypoxic vasodilation via βCys93
Alfred Hausladen, Zhaoxia Qian, Rongli Zhang, Richard T. Premont and Jonathan S. Stamler

Journal of Pharmacology and Experimental Therapeutics May 5, 2022, JPET-AR-2022-001194; DOI: https://doi.org/10.1124/jpet.122.001194
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Treatment of γ-Hydroxybutyrate (GHB) Overdose with the GABA_B Antagonist SGS742
Kristin E Follman and Marilyn E. Morris

Journal of Pharmacology and Experimental Therapeutics May 3, 2022, JPET-AR-2022-001108; DOI: https://doi.org/10.1124/jpet.122.001108
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Fate determination role of erythropoietin and romiplostim in the lineage commitment of hematopoietic progenitors
Xiaoqing Fan, Wojciech Krzyzanski, Raymond S. M. Wong and Xiaoyu Yan

Journal of Pharmacology and Experimental Therapeutics April 30, 2022, JPET-AR-2022-001130; DOI: https://doi.org/10.1124/jpet.122.001130
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Preclinical assessment of the abuse potential of purified botanical cannabidiol: self-administration, drug discrimination, and physical dependence
Royston A Gray, David J Heal, David R. Maguire, Lisa R. Gerak, Martin A. Javors, Sharon Smith and Charles P. France

Journal of Pharmacology and Experimental Therapeutics April 30, 2022, JPET-AR-2021-000988; DOI: https://doi.org/10.1124/jpet.121.000988
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Role of Efficacy as a Determinant of Locomotor Activation by Mu Opioid Receptor Ligands in Female and Male Mice
Edna J. Santos, Matthew L. Banks and S Stevens Negus

Journal of Pharmacology and Experimental Therapeutics April 30, 2022, JPET-AR-2021-001045; DOI: https://doi.org/10.1124/jpet.121.001045
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Pharmacokinetic/Pharmacodynamic Assessment of Selective Phosphodiesterase Inhibitors in a Mouse Model of Autoimmune Hepatitis
Artur Świerczek, Bartosz Pomierny, Elżbieta Wyska and William J. Jusko

Journal of Pharmacology and Experimental Therapeutics May 2022, 381 (2) 151-163; DOI: https://doi.org/10.1124/jpet.121.001004
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ML355 Modulates Platelet Activation and Prevents ABT-737 Induced Apoptosis in Platelets
Valentina Shpakova, Natalia Rukoyatkina, Nada Al Arawe, Anna Prilepskaya, Alexandra Kharazova, Iraida Sharina, Stepan Gambaryan and Emil Martin

Journal of Pharmacology and Experimental Therapeutics May 2022, 381 (2) 164-175; DOI: https://doi.org/10.1124/jpet.121.000973
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Inhibition of Full Smooth Muscle Contraction in Isolated Human Detrusor Tissues by Mirabegron Is Limited to Off-Target Inhibition of Neurogenic Contractions
Ru Huang, Alexander Tamalunas, Raphaela Waidelich, Frank Strittmatter, Christian G. Stief and Martin Hennenberg

Journal of Pharmacology and Experimental Therapeutics May 2022, 381 (2) 176-187; DOI: https://doi.org/10.1124/jpet.121.001029

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