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Lysophosphatidic Acid Receptor Agonism: Discovery of Potent Nonlipid Benzofuran Ethanolamine Structures
Etienne Guillot, Jean-Christophe Le Bail, Pascal Paul, Valérie Fourgous, Pascale Briand, Michel Partiseti, Bruno Cornet, Philip Janiak and Christophe Philippo

Journal of Pharmacology and Experimental Therapeutics August 2020, 374 (2) 283-294; DOI: https://doi.org/10.1124/jpet.120.265454
Open Access
MK-8719, a Novel and Selective O-GlcNAcase Inhibitor That Reduces the Formation of Pathological Tau and Ameliorates Neurodegeneration in a Mouse Model of Tauopathy
Xiaohai Wang, Wenping Li, Jacob Marcus, Michelle Pearson, Lixin Song, Karen Smith, Giuseppe Terracina, Julie Lee, Kwok-Lam Karen Hong, Sherry X. Lu, Lynn Hyde, Shu-Cheng Chen, David Kinsley, Jerry P. Melchor, Daniel J. Rubins, Xiangjun Meng, Eric Hostetler, Cyrille Sur, Lili Zhang, Joel B. Schachter, J. Fred Hess, Harold G. Selnick, David J. Vocadlo, Ernest J. McEachern, Jason M. Uslaner, Joseph L. Duffy and Sean M. Smith

Journal of Pharmacology and Experimental Therapeutics August 2020, 374 (2) 252-263; DOI: https://doi.org/10.1124/jpet.120.266122
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3,4-Methylenedioxypyrovalerone: Neuropharmacological Impact of a Designer Stimulant of Abuse on Monoamine Transporters
Charlotte P. Magee, Christopher L. German, Yasmeen H. Siripathane, Peter S. Curtis, David J. Anderson, Diana G. Wilkins, Glen R. Hanson and Annette E. Fleckenstein

Journal of Pharmacology and Experimental Therapeutics August 2020, 374 (2) 273-282; DOI: https://doi.org/10.1124/jpet.119.264895
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Heterologous Expression and Functional Characterization of Novel CYP2C9 Variants Identified in the Alaska Native People
Matthew G. McDonald, Lindsay M. Henderson, Sutapa Ray, Catherine K. Yeung, Amanda L. Johnson, John P. Kowalski, Helmut Hanenberg, Constanze Wiek, Kenneth E. Thummel and Allan E. Rettie

Journal of Pharmacology and Experimental Therapeutics August 2020, 374 (2) 233-240; DOI: https://doi.org/10.1124/jpet.120.265850
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[³H]Dopamine Uptake through the Dopamine and Norepinephrine Transporters is Decreased in the Prefrontal Cortex of Transgenic Mice Expressing HIV-1 Transactivator of Transcription Protein
Matthew Strauss, Bernadette O’Donovan, Yizhi Ma, Ziyu Xiao, Steven Lin, Michael T. Bardo, Pavel I. Ortinski, Jay P. McLaughlin and Jun Zhu

Journal of Pharmacology and Experimental Therapeutics August 2020, 374 (2) 241-251; DOI: https://doi.org/10.1124/jpet.120.266023
Open Access
ELX-02 Generates Protein via Premature Stop Codon Read-Through without Inducing Native Stop Codon Read-Through Proteins
Daniel K. Crawford, Iris Alroy, Neal Sharpe, Matthew M. Goddeeris and Greg Williams

Journal of Pharmacology and Experimental Therapeutics August 2020, 374 (2) 264-272; DOI: https://doi.org/10.1124/jpet.120.265595
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Comparative Pharmacokinetics of Δ⁹-Tetrahydrocannabinol in Adolescent and Adult Male Mice
Alexa Torrens, Valentina Vozella, Hannah Huff, Brandon McNeil, Faizy Ahmed, Andrea Ghidini, Stephen V. Mahler, Marilyn A. Huestis, Aditi Das and Daniele Piomelli

Journal of Pharmacology and Experimental Therapeutics July 2020, 374 (1) 151-160; DOI: https://doi.org/10.1124/jpet.120.265892
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Evolution of the Systems Pharmacokinetics-Pharmacodynamics Model for Antibody-Drug Conjugates to Characterize Tumor Heterogeneity and In Vivo Bystander Effect
Aman P. Singh, Gail M. Seigel, Leiming Guo, Ashwni Verma, Gloria Gao-Li Wong, Hsuan-Ping Cheng and Dhaval K. Shah

Journal of Pharmacology and Experimental Therapeutics July 2020, 374 (1) 184-199; DOI: https://doi.org/10.1124/jpet.119.262287
Open Access
Parsaclisib Is a Next-Generation Phosphoinositide 3-Kinase δ Inhibitor with Reduced Hepatotoxicity and Potent Antitumor and Immunomodulatory Activities in Models of B-Cell Malignancy
Niu Shin, Matthew Stubbs, Holly Koblish, Eddy W. Yue, Maxim Soloviev, Brent Douty, Kathy He Wang, Qian Wang, Mingming Gao, Patricia Feldman, Gengjie Yang, Leslie Hall, Michael Hansbury, Sybil O’Connor, Lynn Leffet, Robert Collins, Kamna Katiyar, Xin He, Paul Waeltz, Paul Collier, Jin Lu, Yun-Long Li, Yanlong Li, Phillip C.C. Liu, Timothy Burn, Maryanne Covington, Sharon Diamond, Dana Shuey, Alan Roberts, Swamy Yeleswaram, Greg Hollis, Brian Metcalf, Wenqing Yao, Reid Huber, Andrew Combs, Robert Newton and Peggy Scherle

Journal of Pharmacology and Experimental Therapeutics July 2020, 374 (1) 211-222; DOI: https://doi.org/10.1124/jpet.120.265538
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Ezetimibe Markedly Reduces Hepatic Triglycerides and Cholesterol in Rats Fed on Fish Oil by Increasing the Expression of Cholesterol Efflux Transporters
Yuji Tanaka, Takanori Ikeda, Hiroshi Ogawa and Toshinori Kamisako

Journal of Pharmacology and Experimental Therapeutics July 2020, 374 (1) 175-183; DOI: https://doi.org/10.1124/jpet.120.265660

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