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Chronic Morphine-Induced Changes in Signaling at the A₃ Adenosine Receptor Contribute to Morphine-Induced Hyperalgesia, Tolerance, and Withdrawal
Timothy M. Doyle, Tally M. Largent-Milnes, Zhoumou Chen, Vasiliki Staikopoulos, Emanuela Esposito, Rebecca Dalgarno, Churmy Fan, Dilip K. Tosh, Salvatore Cuzzocrea, Kenneth A. Jacobson, Tuan Trang, Mark R. Hutchinson, Gary J. Bennett, Todd W. Vanderah and Daniela Salvemini

Journal of Pharmacology and Experimental Therapeutics August 2020, 374 (2) 331-341; DOI: https://doi.org/10.1124/jpet.120.000004
Open Access
Nonclinical Characterization of the Hypoxia-Inducible Factor Prolyl Hydroxylase Inhibitor Roxadustat, a Novel Treatment of Anemia of Chronic Kidney Disease
Ughetta del Balzo, Pierre E. Signore, Gail Walkinshaw, Todd W. Seeley, Mitchell C. Brenner, Qingjian Wang, Guangjie Guo, Michael P. Arend, Lee A. Flippin, F. Aisha Chow, David C. Gervasi, Christian H. Kjaergaard, Ingrid Langsetmo, Volkmar Guenzler, David Y. Liu, Steve J. Klaus, Al Lin and Thomas B. Neff

Journal of Pharmacology and Experimental Therapeutics August 2020, 374 (2) 342-353; DOI: https://doi.org/10.1124/jpet.120.265181
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Pharmacological Properties of δ-Opioid Receptor–Mediated Behaviors: Agonist Efficacy and Receptor Reserve
Isaac J. Dripps, Ruizhuo Chen, Amanda M. Shafer, Kathryn E. Livingston, Alexander Disney, Stephen M. Husbands, John R. Traynor, Kenner C. Rice and Emily M. Jutkiewicz

Journal of Pharmacology and Experimental Therapeutics August 2020, 374 (2) 319-330; DOI: https://doi.org/10.1124/jpet.119.262717
Open Access
Voltage-Dependent Anion Channels Influence Cytotoxicity of ME-344, a Therapeutic Isoflavone
Leilei Zhang, Danyelle M. Townsend, Morgan Morris, Eduardo N. Maldonado, Yu-Lin Jiang, Ann-Marie Broome, Jennifer R. Bethard, Lauren E. Ball and Kenneth D. Tew

Journal of Pharmacology and Experimental Therapeutics August 2020, 374 (2) 308-318; DOI: https://doi.org/10.1124/jpet.120.000009
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In Vitro Inhibition of Human Aldehyde Oxidase Activity by Clinically Relevant Concentrations of Gefitinib and Erlotinib: Comparison with Select Metabolites, Molecular Docking Analysis, and Impact on Hepatic Metabolism of Zaleplon and Methotrexate
Wee Kiat Tan, Alyssa Rui Yi Tan, Punitha Sivanandam, Ernest Jing Hui Goh, Ze Ping Yap, Nur Fazilah Saburulla, Karl Austin-Muttitt, Jonathan G.L. Mullins and Aik Jiang Lau

Journal of Pharmacology and Experimental Therapeutics August 2020, 374 (2) 295-307; DOI: https://doi.org/10.1124/jpet.120.265249
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Lysophosphatidic Acid Receptor Agonism: Discovery of Potent Nonlipid Benzofuran Ethanolamine Structures
Etienne Guillot, Jean-Christophe Le Bail, Pascal Paul, Valérie Fourgous, Pascale Briand, Michel Partiseti, Bruno Cornet, Philip Janiak and Christophe Philippo

Journal of Pharmacology and Experimental Therapeutics August 2020, 374 (2) 283-294; DOI: https://doi.org/10.1124/jpet.120.265454
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Neuroimmune mechanisms and sex/gender-dependent effects in the pathophysiology of mental disorders
Alexandros G Kokkosis and Stella E Tsirka

Journal of Pharmacology and Experimental Therapeutics July 15, 2020, jpet.120.266163; DOI: https://doi.org/10.1124/jpet.120.266163
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3,4-Methylenedioxypyrovalerone: Neuropharmacological Impact of a Designer Stimulant of Abuse on Monoamine Transporters
Charlotte P. Magee, Christopher L. German, Yasmeen H. Siripathane, Peter S. Curtis, David J. Anderson, Diana G. Wilkins, Glen R. Hanson and Annette E. Fleckenstein

Journal of Pharmacology and Experimental Therapeutics August 2020, 374 (2) 273-282; DOI: https://doi.org/10.1124/jpet.119.264895
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Heterologous Expression and Functional Characterization of Novel CYP2C9 Variants Identified in the Alaska Native People
Matthew G. McDonald, Lindsay M. Henderson, Sutapa Ray, Catherine K. Yeung, Amanda L. Johnson, John P. Kowalski, Helmut Hanenberg, Constanze Wiek, Kenneth E. Thummel and Allan E. Rettie

Journal of Pharmacology and Experimental Therapeutics August 2020, 374 (2) 233-240; DOI: https://doi.org/10.1124/jpet.120.265850
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[³H]Dopamine Uptake through the Dopamine and Norepinephrine Transporters is Decreased in the Prefrontal Cortex of Transgenic Mice Expressing HIV-1 Transactivator of Transcription Protein
Matthew Strauss, Bernadette O’Donovan, Yizhi Ma, Ziyu Xiao, Steven Lin, Michael T. Bardo, Pavel I. Ortinski, Jay P. McLaughlin and Jun Zhu

Journal of Pharmacology and Experimental Therapeutics August 2020, 374 (2) 241-251; DOI: https://doi.org/10.1124/jpet.120.266023

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