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Inhibiting Sialidase-Induced TGF-β1 Activation Attenuates Pulmonary Fibrosis in Mice
Tejas R. Karhadkar, Thomas D. Meek and Richard H. Gomer

Journal of Pharmacology and Experimental Therapeutics January 2021, 376 (1) 106-117; DOI: https://doi.org/10.1124/jpet.120.000258
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A Preclinical Safety Study of Thyroid Hormone Instilled into the Lungs of Healthy Rats—an Investigational Therapy for ARDS
Craig M. Flory, Beverly J. Norris, Nicole A. Larson, Lia G. Coicou, Brenda L. Koniar, Margaret A. Mysz, Timothy P. Rich, David H. Ingbar and Robert J. Schumacher

Journal of Pharmacology and Experimental Therapeutics January 2021, 376 (1) 74-83; DOI: https://doi.org/10.1124/jpet.120.000060
Open Access
Mechanistic Analysis of an Extracellular Signal–Regulated Kinase 2–Interacting Compound that Inhibits Mutant BRAF-Expressing Melanoma Cells by Inducing Oxidative Stress
Ramon Martinez, Weiliang Huang, Ramin Samadani, Bryan Mackowiak, Garrick Centola, Lijia Chen, Ivie L. Conlon, Kellie Hom, Maureen A. Kane, Steven Fletcher and Paul Shapiro

Journal of Pharmacology and Experimental Therapeutics January 2021, 376 (1) 84-97; DOI: https://doi.org/10.1124/jpet.120.000266
Open Access
Functional Interaction of Endothelin Receptors in Mediating Natriuresis Evoked by G Protein–Coupled Estrogen Receptor 1
Eman Y. Gohar and David M. Pollock

Journal of Pharmacology and Experimental Therapeutics January 2021, 376 (1) 98-105; DOI: https://doi.org/10.1124/jpet.120.000322
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Different anti-oxidative and anti-apoptotic effects of piceatannol and resveratrol.
Ryusuke Hosoda, Hiroki Hamada, Daisuke Uesugi, Naotoshi Iwahara, Iyori Nojima, Yoshiyuki Horio and Atsushi Kuno

Journal of Pharmacology and Experimental Therapeutics December 17, 2020, JPET-AR-2020-000096; DOI: https://doi.org/10.1124/jpet.120.000096
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Discovery of M5049: A Novel Selective TLR7/8 Inhibitor for Treatment of Autoimmunity
Jaromir Vlach, Andrew T Bender, Melinda Przetak, Albertina Pereira, Aditee Deshpande, Theresa Johnson, Sonja Reissig, Evgeni Tzvetkov, Djordje Musil, Noune Tahmassian-Morse, Phillip Haselmayer, Simone Favre-Zimmerli, Shinji L Okitsu, Robert L. Walsky and Brian Sherer

Journal of Pharmacology and Experimental Therapeutics December 16, 2020, JPET-AR-2020-000275; DOI: https://doi.org/10.1124/jpet.120.000275
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A phenyl pyrrolidine derivative reveals a dual inhibition mechanism of myocardial mitochondrial permeability transition pore, which is limited by its myocardial distribution.
mathieu panel, Abdelhakim Ahmed-Belkacem, Isaac Ruiz, jean-françois Guichou, jean-michel pawlotsky, bijan ghaleh and didier morin

Journal of Pharmacology and Experimental Therapeutics December 15, 2020, JPET-AR-2020-000359; DOI: https://doi.org/10.1124/jpet.120.000359
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Activation of the G protein-coupled estrogen receptor prevented the development of acute colitis by protecting the crypt cell
Qian Wang, Zhao Li, Kaixuan Liu, Jianbo Liu, Shiquan Chai, Guanyu Chen, Shuyu Wen, Tian Ming, Jiayi Wang, Yuntao Ma, Honghui Zeng, Chuanyong Liu and Bing Xue

Journal of Pharmacology and Experimental Therapeutics December 14, 2020, JPET-AR-2020-000216; DOI: https://doi.org/10.1124/jpet.120.000216
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Downregulation of the αvβ6 integrin via RGD engagement is affinity- and time-dependent.
James Alexander Roper, Alex L Wilkinson, Elaine Gower and Robert J Slack

Journal of Pharmacology and Experimental Therapeutics December 14, 2020, JPET-AR-2020-000379; DOI: https://doi.org/10.1124/jpet.120.000379
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β3-adrenergic receptor agonist prevents diastolic dysfunction in an angiotensin II-induced cardiomyopathy mouse model
Masataka Kamiya, Kuniya Asai, Yasuhiro Maejima, Akihiro Shirakabe, Koji Murai, Satsuki Noma, Hidenori Komiyama, Naoki Sato and Wataru Shimizu

Journal of Pharmacology and Experimental Therapeutics December 14, 2020, JPET-AR-2020-000140; DOI: https://doi.org/10.1124/jpet.120.000140

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