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Journal of Pharmacology and Experimental Therapeutics

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Latest Articles

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    Inhibiting Sialidase-Induced TGF-β1 Activation Attenuates Pulmonary Fibrosis in Mice
    Tejas R. Karhadkar, Thomas D. Meek and Richard H. Gomer
    Journal of Pharmacology and Experimental Therapeutics January 2021, 376 (1) 106-117; DOI: https://doi.org/10.1124/jpet.120.000258
  • You have access
    A Preclinical Safety Study of Thyroid Hormone Instilled into the Lungs of Healthy Rats—an Investigational Therapy for ARDS
    Craig M. Flory, Beverly J. Norris, Nicole A. Larson, Lia G. Coicou, Brenda L. Koniar, Margaret A. Mysz, Timothy P. Rich, David H. Ingbar and Robert J. Schumacher
    Journal of Pharmacology and Experimental Therapeutics January 2021, 376 (1) 74-83; DOI: https://doi.org/10.1124/jpet.120.000060
  • Open Access
    Mechanistic Analysis of an Extracellular Signal–Regulated Kinase 2–Interacting Compound that Inhibits Mutant BRAF-Expressing Melanoma Cells by Inducing Oxidative Stress
    Ramon Martinez, Weiliang Huang, Ramin Samadani, Bryan Mackowiak, Garrick Centola, Lijia Chen, Ivie L. Conlon, Kellie Hom, Maureen A. Kane, Steven Fletcher and Paul Shapiro
    Journal of Pharmacology and Experimental Therapeutics January 2021, 376 (1) 84-97; DOI: https://doi.org/10.1124/jpet.120.000266
  • Open Access
    Functional Interaction of Endothelin Receptors in Mediating Natriuresis Evoked by G Protein–Coupled Estrogen Receptor 1
    Eman Y. Gohar and David M. Pollock
    Journal of Pharmacology and Experimental Therapeutics January 2021, 376 (1) 98-105; DOI: https://doi.org/10.1124/jpet.120.000322
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    Different anti-oxidative and anti-apoptotic effects of piceatannol and resveratrol.
    Ryusuke Hosoda, Hiroki Hamada, Daisuke Uesugi, Naotoshi Iwahara, Iyori Nojima, Yoshiyuki Horio and Atsushi Kuno
    Journal of Pharmacology and Experimental Therapeutics December 17, 2020, JPET-AR-2020-000096; DOI: https://doi.org/10.1124/jpet.120.000096
  • You have access
    Discovery of M5049: A Novel Selective TLR7/8 Inhibitor for Treatment of Autoimmunity
    Jaromir Vlach, Andrew T Bender, Melinda Przetak, Albertina Pereira, Aditee Deshpande, Theresa Johnson, Sonja Reissig, Evgeni Tzvetkov, Djordje Musil, Noune Tahmassian-Morse, Phillip Haselmayer, Simone Favre-Zimmerli, Shinji L Okitsu, Robert L. Walsky and Brian Sherer
    Journal of Pharmacology and Experimental Therapeutics December 16, 2020, JPET-AR-2020-000275; DOI: https://doi.org/10.1124/jpet.120.000275
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    A phenyl pyrrolidine derivative reveals a dual inhibition mechanism of myocardial mitochondrial permeability transition pore, which is limited by its myocardial distribution.
    mathieu panel, Abdelhakim Ahmed-Belkacem, Isaac Ruiz, jean-françois Guichou, jean-michel pawlotsky, bijan ghaleh and didier morin
    Journal of Pharmacology and Experimental Therapeutics December 15, 2020, JPET-AR-2020-000359; DOI: https://doi.org/10.1124/jpet.120.000359
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    Activation of the G protein-coupled estrogen receptor prevented the development of acute colitis by protecting the crypt cell
    Qian Wang, Zhao Li, Kaixuan Liu, Jianbo Liu, Shiquan Chai, Guanyu Chen, Shuyu Wen, Tian Ming, Jiayi Wang, Yuntao Ma, Honghui Zeng, Chuanyong Liu and Bing Xue
    Journal of Pharmacology and Experimental Therapeutics December 14, 2020, JPET-AR-2020-000216; DOI: https://doi.org/10.1124/jpet.120.000216
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    Downregulation of the αvβ6 integrin via RGD engagement is affinity- and time-dependent.
    James Alexander Roper, Alex L Wilkinson, Elaine Gower and Robert J Slack
    Journal of Pharmacology and Experimental Therapeutics December 14, 2020, JPET-AR-2020-000379; DOI: https://doi.org/10.1124/jpet.120.000379
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    β3-adrenergic receptor agonist prevents diastolic dysfunction in an angiotensin II-induced cardiomyopathy mouse model
    Masataka Kamiya, Kuniya Asai, Yasuhiro Maejima, Akihiro Shirakabe, Koji Murai, Satsuki Noma, Hidenori Komiyama, Naoki Sato and Wataru Shimizu
    Journal of Pharmacology and Experimental Therapeutics December 14, 2020, JPET-AR-2020-000140; DOI: https://doi.org/10.1124/jpet.120.000140

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ISSN 1521-0103 (Online)

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