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Sphingosine kinase inhibition enhances dimerization of calreticulin at the cell surface in mitoxantrone-induced immunogenic cell death.
Asvelt J. Nduwumwami, Jeremy A Hengst and Jong K. Yun

Journal of Pharmacology and Experimental Therapeutics June 22, 2021, JPET-AR-2021-000629; DOI: https://doi.org/10.1124/jpet.121.000629
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Enhancing target tissue levels and diminishing plasma clearance of ionizing zwitterionic antidotes in organophosphate exposures.
Yan-Jye Shyong, Yadira Sepulveda, Arnold Garcia, Nathan M. Samskey, Zoran Radic', Rakesh Sit, K. Barry Sharpless, Jeremiah D. Momper and Palmer W Taylor

Journal of Pharmacology and Experimental Therapeutics June 18, 2021, JPET-AR-2021-000715; DOI: https://doi.org/10.1124/jpet.121.000715
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A novel selective PKR inhibitor restores cognitive deficits and neurodegeneration in Alzheimer's disease experimental model
Matilde Lopez-Grancha, Patrick Bernardelli, Nicolas Moindrot, Elisabeth Genet, Carine Vincent, Valerie Roudieres, Alain Krick, Jean-Francois Sabuco, David Machnik, Delphine Ibghi, Laurent Pradier and Veronique Taupin

Journal of Pharmacology and Experimental Therapeutics June 16, 2021, JPET-AR-2021-000590; DOI: https://doi.org/10.1124/jpet.121.000590
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"Nose-to-brain delivery of dexamethasone: biodistribution studies in mice"
Iván Nicolás Pérez Osorio, Alejandro Espinosa, Manuel Giraldo Velázquez, Patricia Padilla, Brandon Bárcena, Gladis Fragoso, Helgi Jung-Cook, Hugo Besedovsky, Gabriela Meneses and Edda Lydia Sciutto Conde

Journal of Pharmacology and Experimental Therapeutics June 16, 2021, JPET-AR-2021-000530; DOI: https://doi.org/10.1124/jpet.121.000530
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Anwulignan ameliorates the intestinal ischemia/reperfusion injury by activating PI3K/AKT signaling pathway in rats
Huijiao Lin, Xinyun Zhang, Dan Wang, Jiawei Liu, Liwei Yuan, Jiale Liu, Chunmei Wang, Jinghui Sun, Jianguang Chen, He Li and Shu Jing

Journal of Pharmacology and Experimental Therapeutics June 15, 2021, JPET-AR-2021-000587; DOI: https://doi.org/10.1124/jpet.121.000587
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Kidney-targeted delivery of PHD2 siRNA with nanoparticles alleviated renal ischemia/reperfusion injury
Dengpiao Xie, Juan Wang, Gaizun Hu, Chaoling Chen, Hu Yang, Joseph K. Ritter, Yun Qu and Ningjun Li

Journal of Pharmacology and Experimental Therapeutics June 8, 2021, JPET-AR-2021-000667; DOI: https://doi.org/10.1124/jpet.121.000667
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Selective PDE1 inhibition ameliorates vascular function, reduces inflammatory response, and lowers blood pressure in ageing animals
Keivan Golshiri, Ehsan Ataei Ataabadi, Eloísa Rubio-Beltran, Sophie Dutheil, Wei Yao, Gretchen L Snyder, Robert E Davis, Ingrid van der Pluijm, Renata Brandt, Ingrid M van den Berg - Garrelds, Antoinette MaassenVanDenBrink, René de Vries, A.H. Jan Danser and Anton J. M. Roks

Journal of Pharmacology and Experimental Therapeutics June 7, 2021, JPET-AR-2021-000628; DOI: https://doi.org/10.1124/jpet.121.000628
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Ginsenoside Ro Ameliorates High-Fat Diet–Induced Obesity and Insulin Resistance in Mice via Activation of the G Protein–Coupled Bile Acid Receptor 5 Pathway
Lin-shan Jiang, Wei Li, Tong-xi Zhuang, Jie-jing Yu, Shuai Sun, Zheng-cai Ju, Zheng-tao Wang, Li-li Ding and Li Yang

Journal of Pharmacology and Experimental Therapeutics June 2021, 377 (3) 441-451; DOI: https://doi.org/10.1124/jpet.120.000435
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Poly(ADP-Ribose) Polymerase Inhibitors for Arsenic Trioxide–Resistant Acute Promyelocytic Leukemia: Synergistic In Vitro Antitumor Effects with Hypomethylating Agents or High-Dose Vitamin C
Manuela Giansanti, Antonio De Gabrieli, Salvatore Pasquale Prete, Tiziana Ottone, Maria Domenica Divona, Terry Karimi, Fabio Ciccarone, Maria Teresa Voso, Grazia Graziani and Isabella Faraoni

Journal of Pharmacology and Experimental Therapeutics June 2021, 377 (3) 385-397; DOI: https://doi.org/10.1124/jpet.121.000537
Open Access
AM833 Is a Novel Agonist of Calcitonin Family G Protein–Coupled Receptors: Pharmacological Comparison with Six Selective and Nonselective Agonists
Madeleine M. Fletcher, Peter Keov, Tin T. Truong, Grace Mennen, Caroline A. Hick, Peishen Zhao, Sebastian G.B. Furness, Thomas Kruse, Trine R. Clausen, Denise Wootten and Patrick M. Sexton

Journal of Pharmacology and Experimental Therapeutics June 2021, 377 (3) 417-440; DOI: https://doi.org/10.1124/jpet.121.000567

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