Abstract
The effect of the intra-arterial injection of DFP and other cholinergic agents on the response of the cat gastrocnemius to maximal single nerve shocks is described.
1. DFP causes a potentiation like that seen following physostigmine.
2. DFP sensitizes the muscle to the close intra-arterial injection of acetylcholine.
3. DFP is less effective in antagonizing the depression of neuromuscular function caused by curare than is prostigmine.
4. Additional evidence is advanced for a direct action of prostigmine on skeletal muscle. ' A comparative study has been made of the actions of DFP, prostigmine, and physostigmine.
5. In relation to these data, the role of cholinesterase in neuromuscular transmission is discussed.
Footnotes
- Received June 4, 1947.
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