Abstract
An in vitro study on the combined antibacterial activity of sulfamido compounds and azochloramid revealed the following:
1. Azochloramid used in combination with suffanilamide, suffathiazol, and and sulfadiazine may exert greater bacteriostatic activity toward Group A hemolytic streptococcus than does either compound alone in like or somewhat higher concentrations.
2. A slight increase in bacteriostatic activity toward Group D hemolytic streptococcus was obtained when azochloramid was used in conjunction with sulfanilamide.
3. The combined use of azochloramid and sulfanilamide, sulfapyridine, sulfathiazol or sulfadiazine resulted in greater inhibition of growth of penumococcus type I than did that of either drug alone in like or somewhat higher concentrations.
4. The combined use of sulfathiazol or sulfadiazine and azochloramid retarded the growth of staphylococcus aureus hemolyticus to a greater extent than did either drug in like or higher concentrations.
Footnotes
- Received September 26, 1941.
JPET articles become freely available 12 months after publication, and remain freely available for 5 years.Non-open access articles that fall outside this five year window are available only to institutional subscribers and current ASPET members, or through the article purchase feature at the bottom of the page.
|