Abstract
Experiments are described which show that the intravenous injection of strophanthin into dogs and cats is regularly followed by the development in the blood of the capacity to cause decrease of tonus and inhibition of contractions in an isolated strip of intestinal muscle in a manner indistinguishable from that possessed by epinephrine. This result is not obtained after section of the splanchnic nerves or of the spinal cord between the fourth and fifth cervical nerves. This is evidence that strophanthin is capable of stimulating the central nervous mechanism controlling the secretion of the suprarenal glands. Experiments are described which indicate that digitoxin has the same capacity in a high degree; but that strychnine and camphor are decidedly less active.
Footnotes
- Received August 21, 1914.
JPET articles become freely available 12 months after publication, and remain freely available for 5 years.Non-open access articles that fall outside this five year window are available only to institutional subscribers and current ASPET members, or through the article purchase feature at the bottom of the page.
|