Abstract
1. The quantitative absorption of alcohol from the gastro-intestinal tracts of cats and dogs is practically identical.
2. The absorption of alcohol from the stomach and small intestine of cats and dogs is about the same; from the colon about a fifth higher.
3. The extent of the absorbing area does not markedly influence the intestinal absorption of alcohol.
4. The absorption of alcohol is scarcely influenced by the concentration of the alcohol, although a 10 per cent solution is absorbed somewhat better than 5, 50 and 95 per cent solutions.
5. The absorption of alcohol from the intestine of cats and dogs is practically arrested at the end of half an hour after injection.
6. The inhibitory effect is of a local nature, since the presence of alcohol in one loop does not inhibit the absorption from adjoining loops. Under certain conditions inhibition may occur systemically.
7. The intravenous injection of alcohol inhibits its absorption from the intestine.
8. Inhibition of the absorption is not due to re-excretion.
9. The percentage absorption of alcohol remains practically constant within wide variations of the systemic blood pressure.
10. Changes in the local circulation influence the intestinal absorption of alcohol.
11. Injury to the intestinal mucosa lessens the absorption of alcohol.
12. The inhibition of the intestinal absorption of alcohol after intravenous injection is due to a slowing of the circulation in the intestine; no such change is demonstrable after local application of the alcohol.
13. Such lipoidal substances as oilve oil, cholesterin, lecithin, soap, bile salts and bile decreased the absoption of alcohol from the intestine of cats and dogs.
14. The absorption of alcohol from the intestine after death averaged 17.6 per cent; from the stomach 27.1 per cent.
15. Local "narcosis" of the intestine, and changes in the concentration of alcohol are not concerned in the inhibition of absorption.
16. The arrest of absorption is due to a retention or "binding" of a certain quantity of alcohol by the intestinal tissues.
Footnotes
- Received October 13, 1913.
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