Abstract
The endogenous gonadal steroid 17β-estradiol (E2) plays an important role in the development, maturation, and function of a wide variety of reproductive and nonreproductive tissues, including those of the nervous system. The actions of E2 at target tissues can be divided into 1) long-term “genomic” actions that are mediated by intracellular estrogen receptor-induced changes in gene expression and 2) rapid actions that modulate a diverse array of intracellular signal transduction cascades. Environmental estrogens are compounds present in the environment that can mimic, and in some cases antagonize, the effects of endogenous estrogens. As a result of these actions, there is currently much interest within the scientific community regarding the relative benefits or threats associated with exposure to different environmental estrogens. Within the general public there is considerable acceptance of the benefits associated with increased use of “natural” estrogens as a component of a healthy diet and in postmenopausal women as an alternative to estrogen replacement therapies. First, this review will focus attention on the role of estrogens in the central nervous system by briefly discussing some of the known mechanisms through which estrogen's effects are mediated, focusing on rapid intracellular signaling mechanisms during neurodevelopment. Second, with the hope of bringing attention to an area of study that until recently has received little consideration, we will briefly discuss phytoestrogens and suggest that these compounds have the potential to influence rapid E2-induced mechanisms in the nervous system in ways that may result in modified brain functions.
Footnotes
- Abbreviations:
- E2
- estradiol
- ER
- estrogen receptor
- ERE
- estrogen-responsive element
- MAPK
- mitogen-activated protein kinase
- CNS
- central nervous system
- CREB
- cAMP-responsive element binding protein
- ERK
- extracellular regulated kinase
- PKA
- protein kinase A
- PKC
- protein kinase C
- PLC
- phospholipase C
- Received April 6, 2001.
- Accepted May 10, 2001.
- The American Society for Pharmacology and Experimental Therapeutics
JPET articles become freely available 12 months after publication, and remain freely available for 5 years.Non-open access articles that fall outside this five year window are available only to institutional subscribers and current ASPET members, or through the article purchase feature at the bottom of the page.
|