Abstract
When tested against six different strains of Schistosoma mansoni, a 6-chlorobenzothia-pyranoindazole analog of hycanthone was found to have antischistosomal activity in mice equal to that of hyeanthone. A hycanthone-resistant strain of S. mansoni proved to be cross-resistant to the analog. Both compounds had similar biochemical effects on schistosomes. The acute toxicity of the analog for mice was lower than that of hycanthone. Since, in contrast to hycanthone, the 6-chloroindazole analog has been shown to have only weak mutagenic activity and to have no detectable teratogenic, malignant cell transforming and hepatotoxic effects, it appears that, within this group of thioxanthenes, mutagenic and other undesirable properties can he dissociated from schistosomicidal activity by suitable structural modifications.
Footnotes
- Received January 11, 1973.
- Accepted May 28, 1973.
- © 1973 by The Williams & Wilkins Co.
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