Abstract
Methamphetamine (15 mg/kg) every six hours produced a significant increase in rat adrenal tyrosine hydroxylase (TH) activity. The enzyme activity in the corpus striatum showed a biphasic response. Striatal TH activity decreased, reached a nadir at 36 hours and progressively returned to normal by about 48 hours. The recovery of the TH activity may be a manifestation of drug tolerance. Cold stress increased adrenal but had no effect on striatal TH activity. Striatal dopamine levels followed the decrease in TH activity but failed to increase as the enzyme recovered. Striatal norepinephrine levels increased initially and did not reflect TH activity.
Footnotes
- Received February 22, 1972.
- Accepted November 29, 1972.
- © 1973 by The Williams & Wilkins Company
JPET articles become freely available 12 months after publication, and remain freely available for 5 years.Non-open access articles that fall outside this five year window are available only to institutional subscribers and current ASPET members, or through the article purchase feature at the bottom of the page.
|
Log in using your username and password
Purchase access
You may purchase access to this article. This will require you to create an account if you don't already have one.