Abstract
Doses of 0.2 and 1.6 mg/kg of methamphetamine (MA) tended to increase low lever-pressing rates and low motor activity levels but were more likely to suppress high-rate lever pressing and motor activity. In addition to this rate dependency, situational variables, such as electric shock, drug dose and time after injection, were also found to influence MA effects. Food intake was reduced only by 1.6 mg/kg of MA. α-Methyltyrosine (αMT) in doses of 12.5 to 50.0 mg/kg caused changes in behavior and was observed to potentiate, antagonize or reverse MA effects depending on the variables described above. This suggests that the effects of α-MT + MA involve several central nervous system mechanisms. α-MT did not interact with p-chloromethamphetamine.
Footnotes
- Received June 22, 1970.
- Accepted September 25, 1970.
- © 1971, by The Williams & Wilkins Company
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