Abstract
The urine and bile of rats injected s.c. with codeine phosphate were chromatographed on columns of Amberlite XAD-2 and IRC-50 resins. Evaporation of the methanolic effluent gave a residue which was purified by recrystallization from aqueous methanol. Paper and thin-layer chromatography, ultraviolet and infrared spectrophotometry, elemental analyses, morphine and glucuronic acid content established the identity of this product as morphine-3-glucuronide dihydrate. Free codeine, morphine, norcodeine and normorphine were identified in the free alkaloid fraction.
Footnotes
- Received October 10, 1969.
- Accepted June 15, 1970.
- © 1970, by The Williams & Wilkins Company
JPET articles become freely available 12 months after publication, and remain freely available for 5 years.Non-open access articles that fall outside this five year window are available only to institutional subscribers and current ASPET members, or through the article purchase feature at the bottom of the page.
|
Log in using your username and password
Purchase access
You may purchase access to this article. This will require you to create an account if you don't already have one.