Abstract
Tubocurarine, dimethyltubocurarine, gallamine and n-C10H21NMe3 have been applied iontophoretically to the end-plate region of frog skeletal muscle fibers. The rate of action of these drugs has been measured by testing the endplate with iontophoretically-applied doses of carbachol. All drugs used act rapidly and behave as if access to the receptor is rate-limiting. Thus no experimental support was obtained for a kinetic model of drug action.
Footnotes
- Received March 13, 1967.
- Accepted May 3, 1967.
- © 1967 by The Williams & Wilkins Company
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